人工流产术后即时放置活性γ型IUD及宫铜200 IUD避孕效果及宫腔液中炎性因子表达变化  

The contraception effect of active γshape IUD and uterine shape copper 200 IUD inserted immediately after induced abortion and the changes of the expression of inflammatory factors in uterine fluid of the women

作　　者：张颖 陈惠群 陈江新 ZHANG Ying;CHEN Huiqun;CHEN Jiangxin(The Eighth Hospital of Wuhan,Wuhan,Hubeiprovince,430010)

机构地区：[1]湖北省武汉市第八医院,430010

出　　处：《中国计划生育学杂志》2020年第7期998-1001,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨活性γ型宫内节育器(IUD)及宫铜200 IUD在人工流产术后即时放置的避孕效果。方法:选取2015年1月—2018年6月在本院行人工流产后自愿放置IUD妇女168例,根据最终选取的IUD类型分组,分别放置活性γ型IUD(94例)或宫铜200 IUD(74例),比较两组临床效果。结果:两组置入IUD 12个月后发生脱器、下移和带器妊娠情况无差异, IUD续用率活性γ型(93.6%)与宫铜200(90.5%)比较无差异(P>0.05),总不良反应发生率活性γ型(16.0%)低于宫铜200(33.8%)(P<0.05);放置后1个月、3个月,活性γ型组宫腔冲洗液血管内皮生长因子(187.28±23.39ng/ml、102.29±21.10ng/ml),白细胞介素-6(64.45±21.10pg/ml、44.50±18.21pg/ml)均低于宫铜200组(220.22±25.51ng/ml、154.48±26.61ng/ml)(98.82±18.82pg/ml、67.71±17.71pg/ml)(P均<0.05)。结论:活性γ型IUD及宫铜200IUD在人工流产术后即时放置均有较好的避孕效果,活性γ型IUD不良反应更少,对宫腔液中炎性因子表达影响更小。Objective:To explore the contraception effect of medicated γ intrauterine device(IUD) and uterine shape copper 200 IUD inserted immediately after induced abortion. Methods: 168 women wanted IUD inserted after abortion immediately were selected and were divided into group A(94 women with activeγshape IUD inserted) and group B(74 women with uterine shape copper 200 IUD inserted) from January 2015 to June 2018. The clinical contraception effect of the women was compared between the two groups. Results: There were no significant difference in the rates of expulsion and moved down of IUD, and the rate of pregnancy with IUD in situ of women between the two groups. The IUD continuation rate of women in group A was 93.6%, which had no significant different from that(90.5%) of women in group B(P>0.05). The total incidence of adverse reactions of women in group A was 16.0%, which was significant lower than that(33.8%) of women in group B(P<0.05). The levels of vascular endothelial growth factor in uterine cavity flushing fluid of women in group A in 1 month and 3 months after IUD inserted was 187.28±23.39 ng/ml and 102.29±21.10 ng/ml, which were significant lower than those(220.22±25.51 ng/ml and 154.48±26.61 ng/ml) of women in group B. And the levels of interleukin 6 in uterine cavity flushing fluid of women in group A in 1 month and 3 months after IUD inserted were 64.45±21.10 pg/ml and 44.50±18.21 pg/ml, which were significant lower than those(98.82±18.82 pg/ml or 67.71±17.71 pg/ml) of women in group B(All P<0.05). Conclusion: The contraceptive effect of both medicated γ IUD and uterine shape copper 200 IUD inserted after abortion immediately is good, but the adverse reaction of medicated γ IUD is less and has little effect on the expression of inflammatory factors in uterine fluid of women.

关 键 词：人工流产术后 宫内节育器 活性γ型 宫铜200 临床效果 血管内皮生长因子 白细胞介素-6 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]