短效复方口服避孕药对人工流产术后卵巢功能的影响  

Effect of combined oral contraceptives on ovarian function of women after induced abortion

作　　者：周芳芳 史娜娜 季玉琴 黄红玲 李莉[1] 谷丽萍 ZHOU Fangfang;SHI Nana;JI Yuqin;HUANG Hongling;LI Li;GU Liping(East Campus of the Sixth People’s Hospital Affiliated to Shanghai Health Medical College,201306)

机构地区：[1]上海健康医学院附属第六人民医院东院,201306

出　　处：《中国计划生育学杂志》2020年第7期1002-1005,共4页Chinese Journal of Family Planning

基　　金：上海市卫生和计划生育委员会(201540362)。

摘　　要：目的:研究短效复方口服避孕药对人工流产术后并发症及卵巢功能的影响。方法:选取2018年1月—2018年6月本院妇产科收治的孕早期行人工流产手术150例,根据流产术后治疗方案分妈富隆组、达英-35组和对照组各50例,比较术后出血、子宫内膜、并发症及不同时间早卵泡期卵巢功能的血清学指标。结果:妈富隆组阴道出血天数、出血量低于达英-35组,且两组均低于对照组;月经按期复潮情况优于达英-35组,且两组均高于对照组(均P<0.05)。妈富隆组与达英-35组术后并发症发生率(0.0%,0.0%)低于对照组(14.0%),术后血清黄体生成素(LH)、雌二醇(E2)、抗苗勒管激素(AMH)、人抑制素B(INH-B)水平高于对照组,卵泡雌激素(FSH)水平低于对照组,窦卵泡数(FN)、血流收缩期峰值(PSV)低于对照组,子宫动脉搏动指数(PI)及子宫内膜血流信号改善情况高于对照组(均P<0.05),但妈富隆组与达英-35组无差异。结论:短效复方口服避孕药能有效改善人工流产术后并发症及卵巢功能,妈富隆与达英-35安全性一致,且治疗效果无明显差异。Objective:To analyze the effect of combined oral contraceptives(COC) on postoperative complications and ovarian function of women after induced abortion. Methods: 150 women after abortion during the first trimester of pregnancy were divided into group A(50 women were given Marvelon), group B(50 women were given Diane-35), and group C(50 women were not given any controceptive) according to their controceptive schedule from January 2018 to June 2018. The bleeding volume after abortion, endometrium situation, complications, and the serological indexes of ovarian function in the early follicular phase of women were compared among these groups. Result: The days and amount of vaginal bleeding of women in group A were the lowest, but those of women in group C were the highest. The rate of menstrual punctual recovery of women in group A was the highest, but that of women in group C was lowest(all P<0.05). The incidence of postoperative complication of women in group A and B were 0.0% and 0.0%, which was significant lower than that(14.0%) of women in group C(P<0.05). The levels of serum LH, E2, AMH, and INH-B, and the improvement of PI value and endometrial blood flow signal of women in group A and B were significant higher than those of women in group C, but the levels of FSH, FN, and PSV were significant lower than those of women in group C(all P<0.05). There were no significant different in the levels of serum LH, E2, AMH, and INH-B, and the improvements of PI value and endometrial blood flow signal, and the levels of FSH, FN, and PSV of women between group A and B. Conclusion: The short acting COC can effectively reduce the postoperative complications and improve ovarian function of women after abortion. And Marvelon and Diane-35 have the same safety and efficacy.

关 键 词：人工流产术后 短效复方口服避孕药 妈富隆 达英-35 卵巢功能:术后并发症 

分 类 号：R169.42[医药卫生—公共卫生与预防医学]