宫颈Cook球囊联合缩宫素滴注与欣普贝生用于足月妊娠引产的临床效果比较  

Clinical efficacy of cervical Cook ripening balloon combined with oxytocin infusion or dinoprostone for induced labor of primiparas in term pregnancy

作　　者：胡娅萍 徐泽荣 欧阳银 HU Yaping;XU Zerong;Ouyang Yin(Hubei Maternal and Child Health Care Hospital affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan,Hubei Province,430000)

机构地区：[1]华中科技大学同济医学院附属湖北省妇幼保健院,武汉430000

出　　处：《中国计划生育学杂志》2020年第7期1044-1047,共4页Chinese Journal of Family Planning

摘　　要：目的:分析宫颈Cook球囊联合缩宫素滴注与欣普贝生用于足月妊娠引产的疗效及安全性。方法:选择本院2017年6月—2018年6月产科收治的345例初产妇为研究对象,按照随机数字表法分为对照组180例和观察组165例,对照组采用欣普贝生引产,观察组采用宫颈Cook球囊联合缩宫素滴注引产,比较两组促宫颈成熟效果,用药前后宫颈Bishop评分、产程、引产中不良反应和预后。结果:用药后,两组宫颈Bishop评分均下降,但组间比较无差异,两组促宫颈成熟总有效率(94.6%、91.1%)比较无差异(均P>0.05)。两组引产至临产及48h内阴道分娩率比较无差异(P>0.05),24h内阴道分娩率观察组(51.5%)低于对照组(70.0%)(P<0.05)。观察组子宫过度刺激、急产(1例,0.6%),胎心监护异常提前取药(球囊)发生率(1例,0.6%)低于对照组(8例,4.4%)(12例,6.7%)(P<0.05),产时发热、产后出血、新生儿Apgar评分、脐动脉pH值比较两组无差异(P>0.05)。结论:宫颈Cook球囊联合缩宫素促宫颈成熟及引产成功率与欣普贝生相似,未增加产褥感染发生风险,但可降低引产过程中胎心异常、子宫过度刺激等不良反应。Objective:To analyze the efficacy and safety of cervical Cook ripening balloon combined with oxytocin infusion or dinoprostone for induced labor of primiparas in term pregnancy.Methods:345 primiparas were selected and were randomly divided into control group and research group according to the random number table from June 2017 to June 2018.180 primiparas in the control group were given dinoprostone for induced labor,and 165 primiparas were given cervical Cook ripening balloon combined with oxytocin infusion for induced labor.The effects of promoting cervical ripening,Bishop scores before and after treatment,duration of labor,rate of adverse reactions during induced labor,and prognosis of primiparas were compared between the two groups.Results:Bishop score of primiparas in the two groups had decreased significantly after treatment,but there was no significant difference between the two groups.There was no significant difference in the total effective rate of promoting cervical ripening(94.6%vs.91.1%)of primiparas between the two groups(all P>0.05).There were no difference in the duration from induced labor begain to near to labour,and the vaginal delivery rate within 48 hours of primiparas between the two groups(P>0.05).The rate of vaginal delivery within 24 hours of primiparas in the research group was 51.5%,which was significant lower than that(70.0%)of primiparas in the control group(P<0.05).The incidences of emergency labor because of uterine hyperstimulation and drugs/balloon withdrawal because of abnormal fetal heart monitoring of primiparas in the research group were 0.6%(1 case)and 0.6%(1 case),which were significant lower than those[4.4%(8 cases)and 6.7%(12 cases)]of primiparas in the control group(P<0.05).There were no significant different in the rates of intrapartum fever and postpartum hemorrhage,and neonatal Apgar score and umbilical artery PH value between the two groups(P>0.05).Conclusion:The cervical Cook balloon combined with oxytocin for promoting cervical ripening and improving induced labor h

关 键 词：足月妊娠引产 宫颈成熟 宫颈Cook球囊 缩宫素 欣普贝生 不良反应 

分 类 号：R719.3[医药卫生—妇产科学]