生血宝合剂辅助治疗妊娠期缺铁性贫血效果及对孕妇MCV、SF及妊娠结局影响  

Effect of Shengxuebao mixture for adjuvant treating pregnant women with iron deficiency anemia and its influence on their levels of mean red blood cell volume and serum ferritin and pregnancy outcomes

作　　者：王奋勤[1] 梁娟丽 王苗苗 张维平[1] WANG Fenqin;LIANG Juanli;WANG Miao;ZHANG Weiping(The First People’s Hospital of Tianshui,Gansu Province,741000)

机构地区：[1]甘肃省天水市第一人民医院,741000

出　　处：《中国计划生育学杂志》2020年第7期1053-1055,1063,共4页Chinese Journal of Family Planning

摘　　要：目的:观察生血宝合剂辅助治疗妊娠期缺铁性贫血对孕妇平均红细胞体积(MCV)、血清铁蛋白(SF)及妊娠结局的影响。方法:选取2017年1月—2018年12月本院收治的缺铁性贫血孕妇120例,随机分组,对照组给予速力菲,观察组速力菲加用生血宝合剂,治疗4周分析治疗后血液相关指标、药物不良反应及妊娠结局。结果:治疗后观察组血红蛋白(Hb)(124.36±6.36 g/L)、红细胞计数(RBC)(3.94±0.45)×1012/L、MCV(97.21±11.41 fL)、SF(20.77±3.26μg/L)、血清铁(SI)(21.32±4.11μmol/L)、铁蛋白饱和度(TSAT)(31.96±5.68)%水平均高于对照组(P<0.05);不良反应发生率(8.3%)、产后出血发生率(1.7%)、胎儿窘迫发生率(5.0%)、早产发生率(2.3%)、低出生体重儿发生率(1.7%)与对照组比较无差异(P>0.05)。结论:生血宝合剂辅助治疗缺铁性贫血可有效改善孕妇血液相关指标水平,提高治疗效果且未增加不良妊娠结局,安全性较好。Objective:To observe the influence of Shengxuebao mixture for adjuvant treating pregnant women with iron deficiency anemia on their levels of mean red blood cell volume(MCV) and serum ferritin(SF) and their pregnancy outcomes. Methods: 120 pregnant women with iron deficiency anemia were divided into two groups from January 2017 to December 2018. The women in the control group were given Zulifei and the women in the observation group were treated with Shengxuebao mixture combined with Zulifei. The levels of blood related indexes, adverse drug reactions, and pregnancy outcomes of the women in the two groups after treating for 4 weeks were analyzed. Results: After treatment, the levels of hemoglobin(Hb), red blood cell count(RBC), MCV level, SF level, serum iron(SI) level, and ferritin saturation(TSAT) of women in the observation group were 124.36±6.36 g/L, 3.94±0.45 ×10^12/L, 97.21±11.41 fL, 20.77±3.26 g/L,1.32±4.11 mol/L, and 31.96±5.68 %, which were significnat higher than those of women in the control group(P<0.05). The incidences of adverse reactions, postpartum hemorrhage, fetal distress, preterm birth, and low birth weight of women in the observation group were 8.3%, 1.7%, 5.0%, 2.3%, and 1.7%, which had no significant different from those of women in the control group(P>0.05). Conclusion: Shengxuebao mixture on for adjuvant therapy pregnant women with iron deficiency anemia can effectively improve their blood related indexes, increase therapeutic effect, and has little adverse effect on pregnancy outcomes with high safety.

关 键 词：妊娠期 缺铁性贫血 生血宝合剂 红细胞体积 血清铁蛋白 妊娠结局 

分 类 号：R714.254[医药卫生—妇产科学]