稽留流产患者VEGF、Hcy及HIF-1α水平及危险因素分析  

Analysis of the levels of VEGF, Hcy and HIF-1αand the risk factors of patients with missed abortion

作　　者：王悦菲 虞丰[1] 秦岭[1] 徐景波 何琳[1] 周晔[1] WANG Yuefei;YU Feng;QIN Ling;XU Jingbo;HE Lin;ZHOU Ye(The Second Hospital of Wuxi Affiliated to Nanjing Medical University,Jiangsu Province,214000)

机构地区：[1]南京医科大学附属无锡二院,214000

出　　处：《中国计划生育学杂志》2020年第7期1078-1081,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨稽留流产患者血清血管内皮生长因子(VEGF)、高同型半胱氨酸(Hcy)及缺氧诱导因子-1α(HIF-1α)水平变化,并分析稽留流产的危险因素。方法:42例稽留流产者为观察组,42例正常妊娠行人工流产者为对照组,比较两组VEGF、Hcy及HIF-1α水平,并对临床资料进行单因素及logistic回归分析。结果:与对照组相比,观察组VEGF及HIF-1α水平降低,Hcy水平升高(均P<0.05);方差分析结果表明,两组高龄、吸烟史、辐射过量、补充叶酸、生育知识了解及甲状腺功能异常占比存在差异(P<0.05),logistic回归分析表明,高龄产妇、吸烟史、辐射过量、甲状腺功能异常及Hcy升高均是稽留流产的危险因素,而补充叶酸、生育知识了解、VEGF及HIF-1α下降是稽留流产的保护因素(均P<0.05)。结论:血清VEGF、Hcy及HIF-1α水平、高龄产妇、吸烟史、辐射过量、补充叶酸、生育知识了解及甲状腺功能异常等均与稽留流产密切相关。Objective:To explore the changes of the levels of serum vascular endothelial growth factor(VEGF), high homocysteine(Hcy), and hypoxia inducible factor-1α(HIF-1α) of patients with missed abortion, and to analyze the risk factors of missed abortion. Methods: 42 patients with missed abortion were included in observation group, and 42 normal pregnant women who wanted induced abortion were included in control group. The levels of VEGF, Hcy and HIF-1α of patients were compared between the two groups. And single factor analysis and logistic regression analysis were used for statistical analysis of the clinical data of patients. Results: The levels of VEGF and HIF-1α of patients in the observation group were significant lower than those of patients in the control group(P<0.05). The results of variance analysis showed that there was significant different in proportions of the older women, smoking history, radiation overdose accepted, folic acid supplementation, knowledge of reproduction, or abnormal thyroid function of patients between the two groups. Logistic regression analysis showed that older women, smoking history, radiation overdose accepted, thyroid dysfunction and Hcy level were the risk factors for missed abortion, while folic acid supplementation, high level of reproductive knowledge, and levels of VEGF and HIF-1α were the protective factors for missed abortion(all P<0.05). Conclusion: The levels of serum VEGF, Hcy and HIF-1α, older women, smoking history, radiation overdose accepted, folic acid supplementation, knowledge level of reproduction, and abnormal thyroid function were all closely related to missed abortion.

关 键 词：稽留流产 血管内皮生长因子 高同型半胱氨酸 缺氧诱导因子-1Α 影响因素 

分 类 号：R714.21[医药卫生—妇产科学]