微生物转化在现代中药研发中的应用  

Application of microbial transformation in the research of modern traditional Chinese medicine

作　　者：李艳[1] 周剑 何东贤 邵倩 朱照静[1] 林一民 Li Yan;Zhou Jian;He Dong-xian;Shao Qian;Zhu Zhao-jing;Lin Yi-min(Chongqing Medical and Pharmaceutical College,Chongqing 401331;Chongqing Institute for Food and Drug Control,Chongqing 401121;Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment,Chongqing University Cancer Hospital,Chongqing 400030)

机构地区：[1]重庆医药高等专科学校,重庆401331 [2]重庆市食品药品检验检测研究院,重庆401121 [3]重庆大学附属肿瘤医院,肿瘤转移与个体化诊治转化研究重庆市重点实验室,重庆400030

出　　处：《中国抗生素杂志》2020年第5期418-422,共5页Chinese Journal of Antibiotics

基　　金：重庆市卫生计生委中医药科技项目(No.ZY201703074)。

摘　　要：微生物转化是指利用微生物的一种或多种酶,在一定条件下,把一种化合物转变为结构相关的有经济价值的另一种化合物。近年来,微生物转化技术越来越多地应用于中药的研发,目的在于提高中药药效,降低毒性,去除杂质,帮助有效成分在体内代谢,产生新的活性成分等。此外,微生物转化具有反应类型广、特异性强、副产物少、反应条件温和可控、环保无污染等优点,在中药转化领域具有独特优势。本文总结了近年来微生物转化技术在中药研发中的应用情况并进行了展望。Microbial transformation refers to using one or more microbial enzymes to convert a compound into another structure-related compound which has economic value under certain conditions. In recent years, microbial transformation technology has been more and more applied to the research of traditional Chinese medicine. The purpose includes improving the efficacy, reducing toxicity, removing impurities, helping the active ingredients to be metabolized in the body, and producing new active ingredients. In addition, microbial transformation has many advantages, such as a wide variety of reaction types, strong specificity, few by-products, mild and controllable reaction conditions, environmental protection and less pollution and thus it has unique advantages in the transformation of traditional Chinese medicine. This article summarizes the application and prospect of microbial transformation technology in the research of traditional Chinese medicine in recent years.

关 键 词：微生物 中药 生物转化 应用 

分 类 号：R932[医药卫生—生药学]