新型冠状病毒肺炎患者血常规及淋巴细胞亚群的变化特点  

Changes of blood routine examination and lymphocyte subsets in patients with COVID-19

作　　者：朱义朗[1] 徐元宏[2] 汪小五 李梅[1] 高勇[1] ZHU Yi-lang;XU Yuan-hong;WANG Xiao-wu;LI Mei;GAO Yong(Department of Clinical Laboratory,Fuyang Second People's Hospital,Fuyang 236000,China;The First Affiliated Hospital of Anhui Medical University)

机构地区：[1]阜阳市第二人民医院检验科,236000 [2]安徽医科大学第一附属医院检验科

出　　处：《天津医药》2020年第7期596-598,共3页Tianjin Medical Journal

基　　金：阜阳市新型冠状病毒感染的肺炎疫情防控应急科研攻关项目(FK20201001)。

摘　　要：目的探讨新型冠状病毒肺炎(COVID-19)患者血常规及淋巴细胞亚群的变化。方法选取2020年1月—2月在阜阳市第二人民医院收治的确诊COVID-19患者66例,将同期住院的疑似并最终排除新型冠状病毒(SARS-CoV-2)感染的56例患者作为对照组。比较2组患者血常规和淋巴细胞亚群水平的差异,Logistic回归分析COVID-19患病的血液细胞学影响因素。结果与对照组相比,COVID-19组白细胞计数(WBC)、中性粒细胞(NEU)、淋巴细胞(LYM)、CD4^+T细胞、CD8^+T细胞、B淋巴细胞水平均降低(P<0.05)。Logistic回归分析显示,CD4+T细胞水平升高是COVID-19患者的保护因素(OR=0.997,95%CI:0.994~0.999),同时CD4+T细胞与LYM计数呈正相关(rs=0.829,P<0.01)。结论COVID-19患者外周血T淋巴细胞水平下降,淋巴细胞亚群分析可为临床诊断SARSCoV-2的感染和治疗提供参考。Objective To investigate the changes of blood routine examination and lymphocyte subsets in patients with coronavirus disease 2019(COVID-19).Methods Sixty-six confirmed COVID-19 patients admitted to Fuyang Second People's Hospital from January to February 2020 were included in this study.Fifty-six patients suspected but ultimately not diagnosed as novel coronavirus(SARS-CoV-2)infection were used as the control group.Changes of blood routine examination and lymphocyte subsets were compared between the two groups.Logistic regression analysis was used for analysing blood cytological factors of COVID-19 patients.Results Compared with the control group,white blood cell(WBC),neutrophils(NEU),lymphocytes(LYM),CD4^+T cells,CD8^+T cells,and B lymphocytes were all reduced in COVID-19 group(P<0.05).Logistic regression analysis showed that the higher levels of CD4^+T-lymphocytes were protective factor for SARS-CoV-2 infection(OR=0.997,95%CI:0.994-0.999).Spearman analysis showed that CD4^+T cells and LYM count were positively correlated(rs=0.829,P<0.01).Conclusion COVID-19 can cause the decrease of peripheral blood T lymphocyte count in patients.T lymphocyte subsets provide relatively reliable reference for clinical diagnosis and treatment of SARS-CoV-2 infection.

关 键 词：肺炎 病毒性 新型冠状病毒肺炎 新型冠状病毒 淋巴细胞 CD4阳性T淋巴细胞 血常规 

分 类 号：R563.12[医药卫生—呼吸系统]