孕期焦虑对早产和低出生体重影响的出生队列研究  

Association of antenatal anxiety with preterm birth and low birth weight:evidence from a birth cohort study

作　　者：鹿孟娟 黄锟[1] 严双琴 朱贝贝 邵珊珊 朱鹏[1] 陶芳标[1] Lu Mengjuan;Huang Kun;Yan Shuangqin;Zhu Beibei;Shao Shanshan;Zhu Peng;Tao Fangbiao(Department of Maternal,Child and Adolescent Health,School of Public Health,Anhui Medical University,Key Laboratory of Population Health Across Life Cycle,Ministry of Education,Key Laboratory of Study on Abnormal Gametes and Reproductive Tract,National Health Commission,Anhui Provincial Key Laboratory of Population Health and Aristogenics,Hefei 230032,China;Ma’anshan Maternal and Child Health Care Hospital,Ma’anshan 243000,China)

机构地区：[1]安徽医科大学公共卫生学院儿少卫生与妇幼保健学系,出生人口健康教育部重点实验室,国家卫生健康委配子及生殖道异常研究重点实验室,人口健康与优生安徽省重点实验室,合肥230032 [2]安徽省马鞍山市妇幼保健院,243000

出　　处：《中华流行病学杂志》2020年第7期1072-1075,共4页Chinese Journal of Epidemiology

基　　金：国家重点研发计划"生殖健康及重大出生缺陷防控研究"重点专项(2016YFC1000204-2);国家自然科学基金(81761128034)。

摘　　要：目的探讨孕期焦虑对早产和低出生体重的影响。方法对孕早期纳入队列的孕妇进行随访,并于孕早、中、晚期运用焦虑自评量表评估焦虑症状,标准评分≥50分界定焦虑症状。采用二元logistic回归模型,分别分析孕早、中、晚期焦虑以及孕中、晚期新发焦虑与新生儿早产和低出生体重之间的关系。结果孕早、中、晚期焦虑的检出率分别为12.5%、3.7%、7.4%。研究发现孕早、中期焦虑与早产之间的关联无统计学意义;孕晚期焦虑会增加子代早产的发生风险(OR=3.55,95%CI:1.62~7.82)。孕早、中、晚期焦虑与低出生体重之间的关联均无统计学意义。孕晚期新发焦虑增加子代早产(OR=5.20,95%CI:1.84~14.70)和低出生体重的发生风险(OR=6.93,95%CI:2.42~19.88)。结论孕晚期焦虑症状是早产重要的危险因素,孕晚期新发的焦虑症状可增加早产和低出生体重的发生风险。Objective To investigate the impacts of antenatal anxiety on preterm birth and low birth weight.Methods Women in early pregnancy were recruited for follow-up,antenatal anxiety in three trimesters was screened using Self-Rating Anxiety Scale and the score≥50 was regarded as anxiety.Logistic regression analysis was conducted to evaluate the associations of the anxiety in three trimesters,new onset anxiety in the second and third trimesters with infant birth outcomes,such as preterm birth and low birth weight.Results The rates of anxiety in the first,second and third trimesters of pregnancy were 12.5%,3.7%,and 7.4%respectively.We found that there was no statistical association between anxiety in the first and second trimester and preterm birth.The anxiety in the third trimester was associated with increased odds for preterm birth(OR=3.55,95%CI:1.62-7.82).Associations between anxiety in all three trimesters and low birth weight were not significant.New onset anxiety in the third trimester was associated with significant increased risk of premature delivery(OR=5.20,95%CI:1.84-14.70)and low birth weight(OR=6.93,95%CI:2.42-19.88).Conclusions Our study showed that anxiety in the third trimester is an important risk factor for premature delivery,new onset anxiety symptoms in the third trimester can significantly increase the incidence of premature birth and low birth weight of infant.

关 键 词：孕期焦虑 早产 低出生体重 

分 类 号：R714.2[医药卫生—妇产科学]