广西壮族自治区男男性行为者HIV非职业暴露后预防效果分析  

Non-occupational post-exposure prophylaxis in men who have sex with men in Guangxi Zhuang Autonomous Region

作　　者：吴雨霏[1] 沈智勇[1] 杨新宇 李荣健[1] 梁能秀[1] 蓝光华[1] Wu Yufei;Shen Zhiyong;Yang Xinyu;Li Rongjian;Liang Nengxiu;Lan Guanghua(Division of HIV/AIDS Prevention and Control,Guangxi Center for Disease Prevention and Control,Nanning 530028,China;U.S.CDC Global AIDS Program,China Office,Beijing 100600,China)

机构地区：[1]广西壮族自治区疾病预防控制中心艾滋病防制所,南宁530028 [2]美国疾病预防控制中心全球艾滋病防治合作项目中国办事处,北京100600

出　　处：《中华流行病学杂志》2020年第7期1086-1091,共6页Chinese Journal of Epidemiology

基　　金：中美艾滋病防治合作项目(5U2GGH001153);广西自然科学基金(2017GXNSFAA198370)。

摘　　要：目的分析广西壮族自治区南宁、柳州市MSM使用抗病毒药物进行HIV非职业暴露后预防(nPEP)效果。方法搭建社会组织-CDC/医院-药店("三位一体")的服务合作模式,通过社区宣传倡导,现场招募研究对象。收集入组研究满28 d参加者的基本信息、药物使用情况和随访检测情况,采用描述性统计进行分析。结果2017年9月至2019年3月,共有213名男男性行为者咨询暴露后预防用药,其中159人符合预防用药标准,接受服药154人。入组研究满28 d的132人,其中连续服药满28 d的118人、未服药满28 d的10人、因失访无法证实是否完成服药的4人。服药满28 d的服务对象中,94.1%(111/118)于暴露后4~6周接受了HIV随访检测,75.4%(89/118)于暴露后3个月接受了HIV随访检测,结果均为阴性。结论在"三位一体"模式下,发生HIV非职业暴露后尽早使用抗病毒药物预防可以降低HIV感染的风险,在一定程度上减少HIV新发感染数。Objective To analyze the effects of HIV non-occupational post-exposure prophylaxis(nPEP)in men who have sex with men(MSM)in Nanning and Liuzhou,Guangxi Zhuang Autonomous Region.Methods Participants were recruited through community publicity and advocacy under a"Trinity"approach among non-governmental organizations(NGO),CDCs/hospitals and pharmacies.Basic information,drug taking and follow-up tests of participants who had enrolled for 28 days of the research were collected.Descriptive statistics were used for data analysis.Results From September 2017 to March 2019,a total of 213 MSM cases consulted for nPEP service,159 of them were eligible for nPEP,and 154 were enrolled in the study for drug taking.For 132 cases enrolled in the study for 28 days and above,118 completed the 28-day course of antiretroviral therapy(ART),while 10 failed to complete the 28-day course of ART,and 4 could not be confirmed whether completed the full course of ART due to loss of contact.For those who completed 28-day course of ART,94.1%(111/118)and 75.4%(89/118)respectively received HIV tests at 4-6 weeks and 3 months after exposure,the results were all HIV negative.Conclusion Under the"Trinity"approach,taking antiviral drugs earlier after HIV non-occupational exposure can effectively reduce the risk of HIV infection and to some extent,reduce the new infection cases.

关 键 词：男男性行为者 HIV非职业暴露后预防 效果分析 

分 类 号：R512.91[医药卫生—内科学]