过氧化氢氧化β-巯基乙醇合成羟乙基磺酸的连续流工艺  

Continuous flow process for synthesizing isethionic acid from oxidation of β-mercaptoethanol by hydrogen peroxide

作　　者：陆雨 严生虎[1,2] 张跃 刘建武[1,2] 沈介发 辜顺林[1,2] 马晓明 陈代祥[1,2] LU Yu;YAN Sheng-hu;ZHANG Yue;LIU Jian-wu;SHEN Jie-fa;GU Shun-lin;MA Xiao-ming;CHEN Dai-xiang(School of Pharmaceutical Engineering&Life Science,Changzhou University,Changzhou 213164,China;Continuous Flow Engineering Laboratory of National Petroleum and Chemical Industry,Changzhou 213164,China)

机构地区：[1]常州大学制药与生命科学学院,江苏常州213164 [2]石油和化工行业连续流技术工程实验室,江苏常州213164

出　　处：《现代化工》2020年第7期217-220,225,共5页Modern Chemical Industry

摘　　要：以β-巯基乙醇为底物,过氧化氢为氧化剂,研究了在微通道反应器液相氧化合成羟乙基磺酸的连续流工艺。实验考察了物料配比、过氧化氢浓度、反应温度、停留时间对氧化反应的影响,在具有特殊微结构的毫米通道微反应器中,物料摩尔比n(H2O2)∶n(β-巯基乙醇)=3.6∶1,H2O2质量分数为40%,反应温度40℃,停留时间120 s,β-巯基乙醇转化率达96.5%,羟乙基磺酸收率达88.1%。此工艺充分利用微通道连续流反应器优良的传质传热特点,大大缩短了反应时间,提高了反应速率,实现对氧化反应过程的有效控制,增加了安全系数。Usingβ-mercaptoethanol as substrate and hydrogen peroxide as oxidant,a continuous flow process for the synthesis of isethionic acid by liquid phase oxidation is studied in a microchannel reactor.The effects of material ratio,hydrogen peroxide concentration,reaction temperature and residence time on the oxidation reaction are investigated through experiments.In the microchannel reactor with special microstructure,the conversion rate ofβ-mercaptoethanol reaches 96.5%and the yield of isethionic acid reaches 88.1%when n(H2O2)∶n(β-mercaptoethanol)is 3.6∶1,H2O2 concentration is 40%,reaction temperature remains at 40℃,and residence time is 120 s.This process utilizes the excellent mass transfer and heat transfer characteristics of the microchannel continuous flow reactor fully,shortens the reaction time greatly,improves the reaction rate,achieves effective control of the oxidation reaction process,and increases the safety factor.

关 键 词：β-巯基乙醇 羟乙基磺酸 氧化 连续流 

分 类 号：TQ227.4[化学工程—有机化工]