辅助生殖技术受孕和自然受孕子痫前期孕妇临床特征的比较  

Comparison of clinical characteristics of preeclampsia between pregnancy with ART and natural pregnancy

作　　者：陈文铭[1] 徐芝慧[2] CHEN Wen-ming;XU Zhi-hui(Department of Obstetrics,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325015,Zhejiang,China;不详)

机构地区：[1]温州医科大学附属第一医院产科,浙江温州325015 [2]温州医科大学附属第一医院生殖中心,浙江温州325015

出　　处：《广东医学》2020年第13期1361-1364,共4页Guangdong Medical Journal

摘　　要：目的比较辅助生殖技术(ART)受孕与自然受孕子痫前期孕妇的临床特点。方法回顾性研究分娩的1 043例子痫前期孕妇的临床病历资料,其中辅助生殖技术受孕的子痫前期孕妇246例(ART组),自然受孕的子痫前期孕妇797例(自然受孕组),对两组孕妇的一般资料、妊娠期并发症及新生儿情况进行比较分析。结果 ART组平均年龄显著高于自然受孕组,孕产次显著低于自然受孕组(P<0.05),ART组多胎妊娠率、早产率、剖宫产率、妊娠期糖尿病(GDM)发生率明显高于自然受孕组(P<0.05)。两组胎死宫内、引产、HELLP综合征、子痫、胎盘早剥等妊娠期并发症发生率比较,差异无统计学意义(P>0.05)。两组新生儿窒息、新生儿死亡率差异无统计学意义(P>0.05)。结论与自然受孕组的子痫前期孕妇相比,ART组的孕妇年龄较大,多胎妊娠率、早产率、剖宫产率及孕妇合并GDM的发生率更高,而两组孕妇子痫前期的临床并发症及新生儿结局没有差异。Objective Comparison of clinical characteristics of preeclam psia between pregnancy with assisted reproductive technology(ART)and natural pregnancy.Methods A retrospective study was carried out on 246 females pregnant with ART and 1043 natural pregnant fem ales,who were diagnosed as preeclam psia in the First Affiliated Hospital of Wenzhou Medical University from January 1,2008 to Decem ber 31,2017.General date,pregnancy complication and neonatal status were compared between the two groups.Results The average age of the ART group was significantly higher than that of the natural pregnancy group,and the gravidity and parity num ber was significantly less than that of the natural pregnancy group(P<0.05).The multiple pregnancy rate,preterm birth rate,cesarean section rate and gestational diabetes mellitus(GDM)rate of the ART group were significantly higher than those of the natural pregnancy group(P<0.05).There was no significant difference in the incidence of pregnancy com plications,such as intrauterine fetal death,induced labor,HELLP syndrom e,eclam psia and placental abruption,between the two groups(P>0.05).There was no significant difference in neonatal asphyxia and neonatal death between the two groups(P>0.05).Conclusion Compared with the natural pregnancy group,the pregnant women in the ART group are older,with higher rates of multiple pregnancy,preterm delivery,cesarean section and GDM.However,there is no difference in two groups in the preeclam psia clinical complications and neonatal outcome.

关 键 词：子痫前期 辅助生殖技术 自然受孕 早产率 剖宫产率 

分 类 号：R715.2[医药卫生—妇产科学] R714[医药卫生—临床医学]