不同年龄、性别的急性心肌梗死患者hs-cTnI诊断阈值及影响因素分析  

Analysis of hs-cTnI diagnostic threshold and influencing factors in patients with acute myocardial infarction of different ages and genders

作　　者：叶丽红 罗浩元[1] 黄思兵[1] 陈潇楷 YE Lihong;LUO Haoyuan;HUANG Sibing;CHEN Xiaokai(Department of Clinical Laboratory,the First People's Hospital of Huizhou City,Guangdong,Huizhou 516000,China)

机构地区：[1]广东省惠州市第一人民医院检验科,广东惠州516000

出　　处：《中国医药科学》2020年第13期122-125,共4页China Medicine And Pharmacy

基　　金：广东省惠州市医疗卫生类科技计划项目(2019Y086)。

摘　　要：目的分析高敏肌钙蛋白I(hs-cTnI)在不同性别、年龄层急性心肌梗死患者中的诊断阈值与影响因素。方法将2018年8月~2019年7月到我院就诊的300例初次检测hs-cTnI的患者作为研究对象,其中非AMI患者共计200例,AMI患者共计100例,将非AMI患者根据年龄的差异分为老年组(≥60岁)和年轻组(<60岁),同时分析不同性别在hs-cTnI方面的差异,确定AMI患者的诊断阈值。结果在非AMI患者中,老年男性患者的hs-cTnI水平明显高于年轻男性患者,差异有统计学意义(P<0.05)。老年女性患者的hs-cTnI水平高于年轻女性患者,差异有统计学意义(P<0.05)。总体男性患者的hs-cTnI水平高于总体女性患者,差异有统计学意义(P<0.05)。经ROC曲线分析,整体AMI患者的最佳诊断阈值为37ng/L,老年男性和老年女性的诊断阈值分别为45ng/L和40ng/L;年龄和性别属于影响患者病死率的重要因素(P<0.05)。结论年龄和性别是影响hs-cTnI水平的关键因素,男性hs-cTnI水平高于女性,hs-cTnI水平与年龄呈正相关,患者年龄与病死率具有一定的关联。Objective To analyze the diagnostic threshold and influencing factors of high-sensitivity troponin I(hs-cTnI)in patients with acute myocardial infarction(AMI)of different genders and ages.Methods 300 cases of hs-cTnI patients who were initially detected in our hospital from August 2018 to July 2019 were selected as the study subjects.Among them,200 were non-AMI patients and 100 were AMI patients.Non-AMI patients were divided into elderly group(≥60 years old)and younger group(<60 years old)according to their age.The differences in hs-cTnI between different genders were analyzed to determine the diagnostic threshold of AMI patients.Results Among non-AMI patients,the hs-cTnI level in elderly male patients was significantly higher than that in young male patients,and the difference was statistically significant(P<0.05).The hs-cTnI level in elderly female patients was higher than that in young female patients,and the difference was statistically significant(P<0.05).The overall level of hs-cTnI in male patients was higher than that in female patients,and the difference was statistically significant(P<0.05).The ROC curve analysis showed that the optimal diagnostic threshold for overall AMI patients was 37ng/L,45ng/L for elderly men and 40ng/L for elderly women,respectively.Age and gender were important factors affecting patient mortality(P<0.05).Conclusion Age and gender are the key factors affecting hs-cTnI level.The hs-cTnI level in men is higher than that in women.The hs-cTnI level is positively correlated with age,and has a certain correlation with patient age and mortality.

关 键 词：高敏cTnI 急性心肌梗死 诊断阈值 影响因素 

分 类 号：R543.3[医药卫生—心血管疾病]