血浆脑钠肽水平与急性心肌梗死部位和预后的关系研究  

Study on the relationship between plasma brain natriuretic peptide level and the site and prognosis of acute myocardial infarction

作　　者：廖春华 李俊宁 邹淑琴 邹云新 徐淑娟 LIAO Chunhua;LI Junning;ZOU Shuqin;ZOU Yunxin;XU Shujuan(Department of Cardiovascular Medicine,People’s Hospital of Fengshun,Guangdong,Fengshun 514322,China)

机构地区：[1]广东省丰顺县人民医院心血管内科,广东丰顺514322

出　　处：《中国医药科学》2020年第13期223-225,247,共4页China Medicine And Pharmacy

基　　金：广东省梅州市科技计划项目(2017B173)。

摘　　要：目的分析血浆脑钠肽(NT-proBNP)水平和急性心肌梗死患者梗死部位及预后之间的关系。方法选取2017年1月~2018年9月本院收治的急性心肌梗死患者160例,根据患者梗死部位的不同将其分为四组,其中下壁梗死患者40例、前间壁梗死患者40例、前侧壁梗死患者40例、前壁梗死患者40例。以酶联免疫吸附法对四组患者的血浆NT-proBNP水平进行测定并进行组间比较。随访1个月,观察研究组患者心血管事件发生情况,比较发生心血管事件患者与未发生心血管事件患者的血浆NT-proBNP水平;比较发生死亡患者与存活事件患者的血浆NT-proBNP水平。结果患者血浆NT-proBNP水平从低到高分别为下壁、前间壁、前侧壁、前壁,四组之间比较,差异有统计学意义(P<0.05)。心血管事件发生率为10%,心血管事件未发生率为90%,发生心血管事件患者的血浆NT-proBNP水平高于未发生心血管事件患者,差异有统计学意义(P<0.05)。随访1年后,死亡患者15例,其中心源性休克死亡7例、肺部感染死亡5例、恶性心律失常死亡3例。发生死亡患者的血浆NT-proBNP水平与存活患者比较,差异无统计学意义(P>0.05)。结论血浆NT-proBNP水平的高低和急性心肌梗死部位及患者预后有密切关系,临床可以将其用于预测梗死部位和预后结果。Objective To analyze the relationship between plasma NT-proBNP(plasma brain natriuretic peptide)level and the infarction site and prognosis in patients with acute myocardial infarction.Methods 160 patients with acute myocardial infarction admitted and treated in our hospital from January 2017 to September 2018 were selected,They were divided into four groups according to different infarct sites,including 40 patients with inferior wall infarction,40 patients with anteriorseptal myocardial infarction,40 patients with anterior lateral wall infarction,and 40 patients with anterior wall infarction.Plasma NT-proBNP levels in the 4 groups of patients were determined by enzyme linked immunosorbent assay,and compared among the groups.1-month follow-up was conducted to observe the incidence of cardiovascular events of patients in the study group,and plasma NT-proBNP levels were compared between patients with and without cardiovascular events;plasma NT-proBNP levels were compared between patients with death and survival events.Results The plasma NT-proBNP levels of patients were inferior wall,anteriorseptal wall,anterior lateral wall,and anterior wall from low to high;the four groups were compared with each other,and the difference was statistically significant(P<0.05).The incidence of cardiovascular events was 10%,and the non-incidence of cardiovascular events was 90%.The plasma NTproBNP level of patients with cardiovascular events was higher than that of patients without cardiovascular events,and the difference was statistically significant(P<0.05).After 1 year of follow-up,15 patients died,including 7 patients from cardiogenic shock,5 patients from pulmonary infection,and 3 patients from malignant arrhythmia.There was no difference in the plasma NT-proBNP level between the patients who died and those who survived,P>0.05.Conclusion The plasma NT-proBNP level is closely correlated with the acute myocardial infarction site and patient prognosis outcome,which can be used clinically to predict the infarction site and prognosi

关 键 词：血浆NT-PROBNP 急性心肌梗死 梗死部位 预后 心血管 

分 类 号：R542.22[医药卫生—心血管疾病]