阿司匹林预防子痫前期及其作用机制的研究进展  

Aspirin in prevention of preeclampsia and its mechanism

作　　者：陈维[1] 王子莲[1] Chen Wei;Wang Zilian(Department of Obstetrics and Gynecology,First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院妇产科,广州510080

出　　处：《中华围产医学杂志》2020年第7期492-495,共4页Chinese Journal of Perinatal Medicine

摘　　要：目前有多个指南建议,有子痫前期高危因素的女性在孕12~34周(最好在孕16周之前)开始服用低剂量阿司匹林,可有效预防子痫前期的发生。阿司匹林预防子痫前期的机制主要包括降低血栓素A2与前列环素的比值;减少血浆可溶性酪氨酸激酶-1的产生;增加滋养细胞的增殖和侵袭,抑制滋养细胞凋亡;作用于炎症反应发挥抗炎作用。本文将对阿司匹林预防子痫前期的机制进行综述。Current guidelines recommend that women with high risk factors for preeclampsia should take low-dose aspirin between 12 to 34 weeks of gestation(preferably before 16 weeks of gestation),in order to effectively reduce the risk of preeclampsia.The mechanism of aspirin in preventing preeclampsia includes lowering the ratio of thromboxane A2 over prostacyclin;decreasing the plasma level of soluble Fms-like tyrosine kinase-1;increasing the proliferation and invasion of trophoblast,whilst inhibiting trophoblast apoptosis;and anti-inflammatory effects.This article reviews the progress on research regarding its mechanism.

关 键 词：阿司匹林 先兆子痫 预防 

分 类 号：R714.244[医药卫生—妇产科学]