冠心病冠状动脉钙化的危险因素及与血清Preptin水平的关系  

Risk factors of coronary artery calcification and its association with serum Preptin level in patients with coronary heart disease

作　　者：石丽媛 芦涤 刘涛 SHI Li-yuan;LU Di;LIU Tao(Department of Cardiology,Hebei Petro China Central Hospital,Langfang,Hebei 065000,China)

机构地区：[1]河北中石油中心医院心内科,河北廊坊065000

出　　处：《中国临床研究》2020年第7期944-947,共4页Chinese Journal of Clinical Research

摘　　要：目的分析冠心病患者冠状动脉钙化(CAC)的危险因素及血清Preptin水平与CAC的关系。方法选取2018年1月至2019年6月收治经冠状动脉CT造影(CTA)确诊的110例冠心病患者作为研究对象,根据CTA的Agatston(CAC评分)法积分将研究对象分为非钙化组(CAC评分=0)和钙化组(CAC评分>0),进行问卷调查和全身体格检查,检测血清生化指标和血清中Preptin水平,采用Student′s t检验和χ^2检验进行CAC危险因素的单因素分析;采用Logistic回归进行CAC危险因素的多因素分析。结果单因素分析结果,钙化组的高血压和糖尿病发生率、年龄和Preptin水平高于非钙化组,差异有统计学意义(P<0.05,P<0.01),显示年龄大、有高血压和糖尿病史、高Preptin水平是CAC的影响因素;进一步进行Logistic回归分析,回归模型为:Logit(P)=-3.130+0.069×年龄+0.880×高血压史+0.812×糖尿病史+0.093×Preptin,结果显示,高Preptin水平、年龄大、有高血压和糖尿病史是CAC的独立危险因素(OR=1.756、1.152、1.753、1.408,P<0.05,P<0.01)。结论冠心病CAC患者血清Preptin水平明显高于非钙化患者,血清Preptin水平增高是CAC的独立危险因素,可能作为CAC诊断的重要指标。Objective To analyze the risk factors of coronary artery calcification(CAC)and the relationship between serum preptin level and CAC in the patients with coronary heart disease.Methods A total of 110 coronary heart disease patients diagnosed by coronary CT angiography(CTA)from January 2018 to June 2019 were selected as study subjects.According to Agatston coronary artery calcium score(CACS),the patients were divided into non-calcification group(CACS=0)and calcification group(CACS>0).Questionnaire survey and physical examination were performed,and serum biochemical indicators and Preptin level were detected.Student′s t-test andχ^2 test were used for single factor analysis of risk factors for CAC;Logistic regression was used to determine the risk factors associated with CAC.Results Univariate analysis showed that the incidence of hypertension and diabetes,age and the level of Pretin in calcification group were statistically higher than those in non-calcification group(P<0.05,P<0.01).Based on the regression model[Logit(P)=3.130+0.069×age+0.880×hypertension+0.812×diabetes+0.093×Preptin],Logistic regression analysis showed that high level of Preprin,old age,hypertension and diabetes history were the independent risk factors of CAC(OR=1.756,1.152,1.753,1.408,respectively,P<0.05 or P<0.01).Conclusions The level of serum Preptin in coronary heart disease patients with CAC is obviously higher than that in patients without calcification.The increased level of serum Preptin is a risk factor for CAC and may be an important indicator for the diagnosis of CAC.

关 键 词：冠心病 PREPTIN 冠状动脉钙化 

分 类 号：R453.3[医药卫生—治疗学]