新斯的明联合电刺激对产后盆底功能障碍性疾病患者盆底功能和肌收缩力的疗效  

Effect of neostigmine combined with electrical stimulation on pelvic floor muscle contractility in patients with postpartum pelvic floor dysfunction

作　　者：胡寒 刘晓芳[1] 卢宗杰[1] HU Han;LIU Xiao-fang;LU Zong-jie(Department of Gynaecology and Obstetrics,Suining Central Hospital,Suining,Sichuan 629000,China)

机构地区：[1]四川省遂宁市中心医院妇产科,四川遂宁629000

出　　处：《中国临床研究》2020年第7期984-987,共4页Chinese Journal of Clinical Research

基　　金：四川省卫生和计划生育委员会科研课题(16PJ528)。

摘　　要：目的探讨新斯的明联合电刺激对产后盆底功能障碍性疾病患者盆底功能恢复、盆底肌收缩力改善的影响及临床疗效。方法选择2017年1月至2019年1月接受治疗的产后盆底功能障碍性疾病患者130例进行研究。采用随机数字表法将患者分为两组,每组65例。对照组行电刺激治疗,观察组在此基础上加用新斯的明治疗。两组均治疗6周后进行评价,对比两组患者临床疗效、功能恢复、盆底肌收缩力、性生活质量及不良反应。结果观察组总有效率为86.15%,高于对照组的70.77%(χ^2=4.552,P<0.05)。治疗后两组患者疲劳度及阴道阻力正常率均显著高于治疗前,且观察组显著高于对照组(P均<0.01)。治疗后两组患者Ⅰ类盆底肌力、Ⅱ类盆底肌力及生活质量评分均显著高于治疗前,且观察组显著高于对照组(P均<0.01)。观察组和对照组不良反应发生率比较差异无统计学意义(4.62%vs 0,χ^2=1.365,P=0.243)。结论新斯的明联合电刺激较单独使用电刺激可明显提高产后盆底功能障碍性疾病患者的治疗有效率,缓解盆底肌疲劳,恢复阴道阻力,提高盆底肌力,改善患者性生活,且不增加不良反应发生率。Objective To investigate the clinical efficacy of neostigmine combined with electrical stimulation on functional recovery and improvement of pelvic floor muscle contractility in patients with postpartum pelvic floor dysfunction.Method A total of 130 patients with postpartum pelvic dysfunction disease treated from January 2017 to January 2019 were selected and randomly divided into control group and observation group(n=65,each).Electrical stimulation therapy was performed in control group,and neostigmine was added based on electrical stimulation therapy in observation group.After 6 weeks of treatment,the clinical efficacy,functional recovery,pelvic floor muscle contractility,sexual function and adverse reactions were compared between two groups.Results The total effective rate in observation group was significantly higher than that in control group(86.15%vs 70.77%,χ^2=4.552,P<0.05).After treatment,the fatigue degree and the percentage of vaginal resistance significantly increased in two groups and were higher in observation group than those in control group(all P<0.01);the scores of classⅠandⅡpelvic floor muscle strength and quality of life were significantly higher than those before treatment in both groups,and were statistically higher in observation group than those in control group(all P<0.01).There was no significant difference in the incidence of adverse reactions between observation group and control group(4.62%vs 0,χ^2=1.365,P=0.243).Conclusion For the patients with postpartum pelvic floor dysfunction,neostigmine combined with electrical stimulation can significantly increase the treatment efficiency,relieve pelvic floor muscle fatigue,restore vaginal resistance,improve pelvic floor muscle strength and the patients′sexual life without increasing the incidence of adverse reactions compared with electrical stimulation alone.

关 键 词：产后盆底功能障碍 新斯的明 电刺激 盆底肌收缩力 盆底肌力 阴道阻力 

分 类 号：R714.6[医药卫生—妇产科学]