儿童自闭症的环境危险因素研究  

Study on Environmental Risk Factors of Children Autism Disorder

作　　者：黄丹妮 金永堂[1] 叶怀庄[2] 田宇[1] 徐晨露 祝子逸[3] 邱丽倩[4] 沈珏[5] 徐迎春[6] HUANG Danni;JIN Yongtang;YE Huaizhuang;TIAN Yu;XU Chenlu;ZHU Ziyi;QIU Liqian;SHEN Jue;XU Yingchun

机构地区：[1]浙江大学医学部公共卫生学院环境医学系,浙江省杭州市311400 [2]浙江大学公共卫生实验教学中心 [3]浙江大学医学院附属邵逸夫医院 [4]浙江大学医学院附属妇产科医院 [5]浙江大学医学院附属儿童医院 [6]浙江大学药学院生化药学研究室

出　　处：《环境卫生学杂志》2020年第3期234-242,共9页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：国家自然科学基金(81673124)。

摘　　要：目的探索儿童自闭症与多种环境危险因素之间的关系。方法选择特殊教育学校和康复机构的儿童为对象,共收集316名自闭症儿童和293名对照儿童的人口学、母亲孕产期和儿童生命早期的相关因素、孕期及生后的交通空气污染和父母环境接触史等信息。应用t检验、卡方检验和多因素logistic回归模型分析儿童自闭症的环境危险因素。结果单因素分析结果显示,自闭症的发生风险与母亲产前抑郁症、母亲日常使用微波炉呈正关联,与母亲妊娠期高血压、辛辣食物的偶尔摄入呈负关联,OR(95%CI)值分别为13.52(1.63,111.93)、1.65(1.06,2.58)、0.34(0.12,0.94)、0.47(0.28,0.78)。多因素logistic回归模型分析显示,儿童自闭症与母亲产前抑郁症、日常使用微波炉呈正关联,OR(95%CI)值分别为12.05(1.46,99.48)和1.67(1.07,2.62);与母亲妊娠期高血压和辛辣食物的偶尔摄入呈负关联,OR(95%CI)值分别为0.29(0.10,0.84)和0.48(0.29,0.82)。结论母亲产前抑郁症、日常使用微波炉可能是儿童自闭症的环境危险因素。Objectives To explore the relationship between autism disorder(AD)and various environmental risk factors.Methods A total of 316 children with AD and 293 controls from some special education schools and rehabilitation institutions were recruited.Demographic information,related factors of maternal prenatal and children’s early-life condition,traffic air pollution during prenatal and postnatal period,parental environmental exposure history and living habits were collected.T test,chi-square test,and multivariate logistic regression model were used to identify the risk factors for the occurrence of AD.Results Univariate analysis showed that the risk of AD was positively related to mothers’prenatal depression,mothers’daily use of microwave ovens,and negatively correlated with maternal hypertension and occasional spicy food intake,OR(95%CI)values were 13.52(1.63,111.93),1.65(1.06,2.58),0.34(0.12,0.94),0.47(0.28,0.78),respectively.Multivariate logistic analysis showed that factors positively associated with AD were maternal prenatal depression and the daily usage of microwave,OR(95%CI)values were12.05(1.46,99.48)and 1.67(1.07,2.62),respectively.Factors negatively associated with AD were maternal gestational hypertension and occasional intake of spicy food,OR(95%CI)values were 0.29(0.10,0.84)and 0.48(0.29,0.82),respectively.Conclusions Maternal prenatal depression and daily usage of microwave may be risk factors of AD.

关 键 词：自闭症 环境 危险因素 

分 类 号：R330.57[医药卫生—人体生理学]