Ⅲ型干扰素相关生物学功能的研究进展  

Update of the biological functions of type Ⅲ interferon

作　　者：洪天旗 陶洁[1,4] 杨溢[1,2,3] 王鹏志 朱国强[1,2,3] Tianqi Hong;Jie Tao;Yi Yang;Pengzhi Wang;Guoqiang Zhu(College of Veterinary Medicine,Yangzhou University,Yangzhou 225009,Jiangsu Province,China;Important Disease Animal and Zoonosis Prevention and Control Collaborative Innovation Center of Jiangsu Province,Yangzhou 225009,Jiangsu Province,China;Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education,Yangzhou University,Yangzhou 225009,Jiangsu Province,China;Institute of Animal Science and Veterinary Medicine,Shanghai Academy of Agricultural Science,Shanghai 201106,China)

机构地区：[1]扬州大学兽医学院,江苏扬州225009 [2]江苏省动物重要疫病与人兽共患病防控协同创新中心,江苏扬州225009 [3]教育部农业与农产品安全国际合作联合实验室,江苏扬州225009 [4]上海市农业科学院畜牧兽医研究所,上海201106

出　　处：《微生物学报》2020年第7期1321-1334,共14页Acta Microbiologica Sinica

基　　金：江苏现代农业(奶牛)产业技术体系(疾病防控创新团队)(JATS[2018]315);江苏高校优势学科建设工程;上海市科技兴农重点推广项目(沪农科推字2017第1-11号)。

摘　　要：干扰素(Interferon,IFN)是一类具有多功能生物活性的糖蛋白,包含3个家族(Ⅰ型、Ⅱ型和Ⅲ型)。Ⅲ型干扰素(TypeⅢinterferon,IFN-Ⅲ)是近16年发现的新型干扰素,其诱导过程及生物学功能与I型干扰素(TypeⅠinterferon,IFN-Ⅰ)相似,在抗病毒、免疫调节、抗肿瘤、抑制自身免疫病、抑制过敏性哮喘以及抗细菌和真菌等方面具有重要作用。本文将从IFN-Ⅰ和IFN-Ⅲ的分类、序列同源性和信号传导等方面进行阐述,并结合近年来IFN-Ⅲ在疾病治疗过程中所取得的成就,综述IFN-Ⅲ的生物学功能,旨在为IFN-Ⅲ的深入研究以及在多种疾病的诊断和防控中提供参考。Interferon(IFN)is a kind of glycoprotein with multifunctional biological activity,and contains three families(typeⅠ,typeⅡand typeⅢ).TypeⅢinterferon(IFN-Ⅲ)is a novel interferon discovered in the last 16 years.The induction process and biological functions of IFN-Ⅲare similar to those of type I interferon(IFN-Ⅰ).IFN-Ⅲplays an important role in antiviral,immunomodulatory,antitumor,suppression of autoimmune diseases,allergic asthma,as well as antibacterial and antifungal.We elaborate here IFN-Ⅰand IFN-Ⅲin terms of classification,sequence homology and signal transduction.Combining with the achievements of IFN-Ⅲin the treatment of diseases in recent years,we try to summarize the related biological functions of IFN-Ⅲ,to provide a reference for further study of IFN-Ⅲ.

关 键 词：Ⅲ型干扰素 生物学功能 信号传导 受体 屏障 

分 类 号：Q51[生物学—生物化学]