207例慢性阻塞性肺疾病患者血栓前状态指标的分析  

Analysis of prethrombotic status indicators in 207 patients with chronic obstructive pulmonary disease

作　　者：李志强[1] 杜艳君[1] 张丽 王宝霞 王秀伟 彭旭涛 Li Zhiqiang;Du Yanjun;Zhang Li;Wang Baoxia;Wang Xiuwei;Peng Xutao(Fangshan District First Hospital,Beijing 102400;Quyang Hospital of Traditional Chinese Medicine,Baoding,Hebei 073199)

机构地区：[1]北京市房山区第一医院,北京102400 [2]河北省保定市曲阳县中医院,河北保定073199

出　　处：《当代医药论丛》2020年第12期7-9,共3页

摘　　要：目的:分析慢性阻塞性肺疾病(COPD)患者病情的严重程度与其血栓前状态(PTS)指标的相关性。方法:选取近年来北京市房山区第一医院收治的207例COPD患者与同期在该医院进行体检的100例健康人作为研究对象。将其中100例健康人设为C组,将这207例COPD患者中病情处于急性加重期的患者设为A组,将其中病情处于稳定期的患者设为B组。同时根据这207例患者的肺功能分级将其分为Ⅰ组(肺功能分级为Ⅰ级)、Ⅱ组(肺功能分级为Ⅱ级)、Ⅲ组(肺功能分级为Ⅲ级)和Ⅳ组(肺功能分级为Ⅳ级)。比较各组研究对象PTS指标〔包括血浆纤维蛋白原(FG)、D-二聚体(D-Dimer)和同型半胱氨酸(HCY)〕的水平。结果:A组患者与B组患者血浆FG、D-Dimer和HCY的水平均高于C组健康人,P<0.05。A组患者血浆FG、D-Dimer和HCY的水平均高于B组患者,P<0.05。Ⅳ组患者血浆FG、D-Dimer和HCY的水平均高于Ⅰ组患者、Ⅱ组患者和Ⅲ组患者,P<0.05。Ⅲ组患者血浆FG、D-Dimer和HCY的水平均高于Ⅰ组患者和Ⅱ组患者,P<0.05。Ⅱ组患者血浆FG、D-Dimer和HCY的水平均高于Ⅰ组患者,P<0.05。结论:COPD患者的病情越严重其PTS指标的水平越高。Objective:To analyze the correlation between severity of chronic obstructive pulmonary disease(COPD)and pre-thrombotic status(PTS)indexes.Methods:207 cases of COPD patients admitted to The First Hospital of Fangshan District,Beijing in recent years and 100 healthy people who underwent physical examination in the hospital during the same period were selected as the research objects.Among them,100 healthy people were set as Group C,207 COPD patients with acute exacerbations were set as Group A,and those with stable conditions were set as group B.At the same time according to the 207 cases of lung function in patients with classifying it intoⅠgroups(pulmonary function class forⅠ),Ⅱgroup(class forⅡlung function),Ⅲgroup(class forⅢlung function)andⅣgroup(class forⅣlung function).PTS levels,including plasma fibrinogen(FG),D-dimer(D-Dimer)and homocysteine(HCY),were compared in each group.Results:The plasma levels of FG,D-Dimer and HCY in group A and Group B were higher than those in group C(P<0.05).The plasma FG,D-Dimer and HCY levels in group A were higher than those in group B(P<0.05).Ⅳpatients plasma FG,D-Dimer and HCY levels were higher thanⅠgroup of patients,patients andⅢⅡgroup group of patients,P<0.05.Ⅲpatients plasma FG,D-Dimer and HCY levels andⅡgroup were higher than inⅠgroup patients,P<0.05.Ⅱpatients plasma FG,D-Dimer and HCY levels were higher thanⅠgroup of patients,P<0.05.Conclusion:The more severe the condition of COPD patie nts,the higher the level of PTS indexes.

关 键 词：慢性阻塞性肺疾病 血栓前状态 纤维蛋白原 D-二聚体 同型半胱氨酸 

分 类 号：R563[医药卫生—呼吸系统]