通窍活血汤治疗中风后认知障碍疗效研究  

Effect of Tongqiao Huoxue Decoction on cognitive dysfunction in patients after stroke

作　　者：刘雅莉[1] 郭健[2] 孙伟娟[2] 白艳杰[2] 张铭[2] 王磊[2] 冯晓东[2] LIU Ya-li;GUO Jian;SUN Wei-juan;BAI Yan-jie;ZHANG Ming;WANG Lei;FENG Xiao-dong(Henan Institute of Medical Information,Zhengzhou,Henan 450046,China;不详)

机构地区：[1]河南省医学情报研究所,河南郑州450046 [2]:2.河南中医药大学第一附属医院康复中心,河南郑州450003

出　　处：《中华全科医学》2020年第9期1560-1562,1576,共4页Chinese Journal of General Practice

基　　金：国家重点研发计划中医药现代化研究重点专项(2018YFC1706004);河南省循证医学资源库平台建设(豫财预[2018]79号)。

摘　　要：目的通过观察通窍活血汤治疗中风后认知功能障碍后遗症患者的临床疗效和安全性,为其在中风后认知功能障碍患者治疗中的应用寻找循证证据。方法选取2017年1月—2018年6月河南中医药大学康复中心收治的符合标准的60例中风后认知障碍患者为研究对象,并将其按入组顺序编号,利用随机数字表法将研究对象随机分为实验组和对照组,各30例,对照组仅给予常规康复功能训练,实验组在常规康复功能训练的基础上给予通窍活血汤加减治疗。于治疗前及治疗4周后测量并比较2组蒙特利尔认知评估量表(MoCA)及日常生活能力(ADL)评分和生命体征与肝肾功能指标,以评估通窍活血汤治疗中风后认知功能障碍的临床疗效。结果治疗前2组蒙特利尔认知评估量表(MoCA)及日常生活能力(ADL)评分等基线资料均衡可比;与治疗前相比,经过4周治疗后实验组与对照组蒙特利尔认知评估量表(MoCA)评分及日常生活能力(ADL)评分均有所提高(MoCA评分实验组分别从16.91±6.13提高至24.07±5.89,对照组从16.73±6.15提高至20.14±6.21;ADL评分实验组从35.16±7.14提高至69.73±9.73,对照组从35.72±9.22提高至51.26±8.46),但实验组提高幅度更加显著,差异均具有统计学意义(均P<0.05)。结论通窍活血汤治疗中风后认知障碍,补虚通窍,疗效显著,值得临床进一步推广。Objective To observe the clinical efficacy and safety of Tongqiao Huoxue Decoction in the treatment of patients with cognitive dysfunction after stroke,and to seek evidence-based evidence for its application in the treatment.Methods Sixty patients with post-stroke cognitive dysfunction admitted to the Rehabilitation Center of Henan University of Traditional Chinese Medicine from January 2017 to June 2018 were selected as the research subjects.According to the random number table,they were divided into experimental group and control group with 30 cases in each group.The control group was given only regular rehabilitation functional training,and the experimental group was given Tongqiao Huoxue Decoction addition and subtraction treatment based on the control group.Before and after 4 weeks of treatment,the Montreal Cognitive Assessment Scale(MoCA)and daily living ability(ADL)scores,vital signs and liver and kidney function indicators of the two groups were measured and compared.Results Before treatment,the baseline data such as MoCA and ADL scores were balanced and comparable.After 4 weeks of treatment,the MoCA and ADL scores of the two groups were improved compared with before treatment.The MoCA score of the experimental group was increased from 16.91±6.13 to 24.07±5.89,and that of the control group was increased from 16.73±6.15 to 20.14±6.21.The ADL scores of the experimental group was increased from 35.16±7.14 to 69.73±9.73,and that of the control group was increased from 35.72±9.22 to 51.26±8.46.Moreover,the increase in the experimental group was more significant,the differences were statistically significant(all P<0.05).Conclusion Tongqiao Huoxue Decoction is effective in treating post-stroke cognitive dysfunction,tonifying the deficiency and opening the orifices,which is worthy of further clinical promotion.

关 键 词：通窍活血汤 中风 认知障碍 疗效研究 

分 类 号：R255.2[医药卫生—中医内科学] R243[医药卫生—中医学]