微波消融联合液体注射的温度场  

Temperature Field in Microwave Ablation Combined With Liquid Injection

作　　者：田甄[1] 程妍妍 高翔 董彤[1] 南群[1] 乔爱科[1] TIAN Zhen;CHENG Yanyan;GAO Xiang;DONG Tong;NAN Qun;QIAO Aike(College of Life Science and Bio-engineering,Beijing University of Technology,Beijing 100124,China)

机构地区：[1]北京工业大学生命科学与生物工程学院,北京100124

出　　处：《北京工业大学学报》2020年第7期803-811,共9页Journal of Beijing University of Technology

基　　金：国家自然科学基金资助项目(31771021);北京市自然科学基金资助项目(3162006);江苏省科技项目(BE2017758)。

摘　　要：为了探讨不同消融功率和肝脏孔隙率条件下,液体注射对微波消融过程中肝脏温度场分布的影响,建立理想的三维对称多孔介质简化模型,模拟微波消融联合液体注射对多孔介质肝脏的作用.在不同的肝脏孔隙率(0.10、0.15、0.20、0.25、0.30)、不同的输入功率(50、60、70 W)和不同的注射液体(生理盐水或无水乙醇)下分析凝固区域.将肝脏孔隙率由0.10增加到0.30,无注射组的消融区域减小,注射生理盐水组的消融区域减小,注射无水乙醇组的消融区域增大,但消融区域变大或减小的趋势并不明显.当消融功率增加(50~70 W),生理盐水组的消融体积比单纯消融组分别增大54.99%、48.73%、32.71%,消融区域的横径由单纯消融组的2.60 cm扩增至3.40 cm;当消融功率增加(50~70 W),无水乙醇组的消融体积比单纯消融组分别增大71.68%、77.99%、73.39%,消融区域的横径由单纯消融组的2.60 cm扩增至3.55 cm,均能达到完全覆盖较大肿瘤(d=3 cm)的目的.对于生理盐水组,逐渐增加消融功率(50~70 W),消融区域的体积分别增大13.89%和6.19%.对于无水乙醇组,逐渐增加消融功率(50~70 W),消融区域的体积分别增大23.06%和15.92%.结果表明:在液体注射联合微波消融的情况下,凝固范围明显扩大.低功率(50 W)注射液体获得的凝固区域优于高功率(70 W)注射液体获得的凝固区域.To investigate the effects of liquid injection on the temperature distribution of porous liver during microwave ablation(MWA)in the conditions of different ablation powers and porosities of liver.In this study,an idealized 3D symmetric simplified model of porous media was built to simulate liquid injection combined with microwave ablation on porous liver.Under different porosities of liver(0.10,0.15,0.20,0.25,and 0.30)and different input powers(50,60,and 70 W)and different injection fluids(saline or anhydrous ethanol)within 300 s,the lesion zones were analyzed.As the porosity increased from 0.10 to 0.30,the ablation area decreased gradually in the non-injection group,and the ablation area of saline group decreased,while that of anhydrous ethanol group increased.However,the ablation area increased or decreased slightly.With the increase of the ablation power(50 to 70 W),the volume of the saline group ablation area increased by 54.99%,48.73%and 32.71%,compared with that of the group without injection,and the radius expanded from 2.60 to 3.40 cm.As for ethanol,the volume increase rate was 71.68%,77.99%and 73.39%and the radius expanded from 2.60 to 3.55 cm.The tumor can be completely ablated(d=3 cm).With the increase of the ablation power(50 to 70 W),the ablation volume in saline group increased by 13.89%and 6.19%,respectively.The ablation volume in ethanol group increased by 23.06%and 15.92%with the increase of the ablation power(50 to 70 W).Results show that the lesion zone expands significantly in the condition of liquid injection combined with the microwave ablation.Lesion zone obtained by injection the liquid at the low power(50 W)is superior to the ablation area without injection at the high power(70 W).

关 键 词：微波消融 多孔介质 肝脏 液体注射 数值仿真 微波天线 

分 类 号：Q65[生物学—生物物理学]