去势抵抗性前列腺癌患者疲乏、疼痛及生活质量的纵向分析  

A longitudinal study of fatigue,pain,and quality of life in patients with metastatic castration-resistant prostate cancer

作　　者：李萍[1] 吴春燕[1] 金珍珍[1] 胡颖颖[2] 李海燕[1] 卢中秋[2] Li Ping;Wu Chunyan;Jin Zhenzhen;Hu Yingying;Li Haiyan;Lu Zhongqiu(Department of Urology,The First Hospital of Wenzhou Medical University,Wenzhou 325000,China)

机构地区：[1]温州医科大学附属第一医院泌尿外科,浙江温州325000 [2]温州医科大学附属第一医院急诊医学中心,浙江温州325000

出　　处：《护理学杂志》2020年第13期27-29,40,共4页Journal of Nursing Science

基　　金：温州市科技局基础性医疗卫生科技项目(Y20180676)。

摘　　要：目的调查转移性去势抵抗性前列腺癌患者的疲乏、疼痛和生活质量情况,并分析生活质量的影响因素。方法采用简明疲乏量表、简明疼痛量表及生活质量测定量表,分别于入组时,入组后2个月、4个月和6个月对127例转移性去势抵抗性前列腺癌患者进行调查。结果入组时,入组后2个月、4个月和6个月患者疲乏得分分别为2.20、2.46、2.20和2.80,疼痛得分为1.66、1.87、1.95和2.10,生活质量得分为90.58、90.23、89.22和88.88,不同时间比较差异有统计学意义(均P<0.01)。治疗方式、体力状态评分、疲乏、疼痛和年龄为生活质量的影响因素(均P<0.01)。结论随着病程的进行,转移性去势抵抗性前列腺癌患者疲乏和疼痛程度逐步加重,生活质量逐步下降。护理人员应早期关注及识别患者生活质量的受损情况,早期护理介入。Objective To investigate the levels of fatigue,pain and quality of life in patients with metastatic castration-resistant prostate cancer(mCRPC),and to analyze the influencing factors of quality of life.Methods A total of 127 patients with mCRPC were surveyed by using the Brief Fatigue Inventory,Brief Pain Inventory and the Functional Assessment of Cancer Therapy-Prostate(FACT-P)at baseline and 2,4 and 6 months after recruitment.Results Fatigue at baseline,2,4 and 6 months after recruitment scored 2.20,2.46,2.20,and 2.80 respectively,pain scores were 1.66,1.87,1.95,and 2.10,and quality of life scored 90.58,90.23,89.22,and 88.88,respectively,each showing significant differences over time(P<0.01 for all).Treatment methods,Eastern Cooperative Oncology Group(ECOG)score,fatigue,pain,and age were factors affecting quality of life(P<0.01 for all).Conclusion As the disease progresses,fatigue and pain become more severe,and quality of life decreases.Nursing staff should pay attention to and identify impaired quality of life of patients at early stage,and intervene early.

关 键 词：去势抵抗性前列腺癌 去势治疗 生活质量 疲乏 疼痛 多西他赛 阿比特龙 

分 类 号：R473.6[医药卫生—护理学]