甲基泼尼松龙冲击治疗儿童难治性肺炎支原体肺炎50例临床观察  

Effect of clinical pulse methylprednisolone therapy on refractory mycoplasma pneumoniae pneumonia in children

作　　者：张艳秋 马一敏 ZHANG Yanqiu;MA Yimin(Peking University Healthcare in Tianjin,Tianjin 300452,China;不详)

机构地区：[1]天津北大医疗海洋石油医院,天津300452 [2]天津泰达医院,天津300457

出　　处：《现代医院》2020年第8期1221-1223,共3页Modern Hospitals

摘　　要：目的探讨甲基泼尼松龙冲击治疗儿童难治性肺炎支原体肺炎对患儿症状体征和炎性因子的影响。方法选择两院儿科2019年1月-2019年12月儿童难治性肺炎支原体肺炎患儿100例,随机分组,常规组(50例)采取常规抗感染、化痰止咳等方法治疗,冲击组(50例)采取常规抗感染、化痰止咳等方法治疗联合甲基泼尼松龙冲击治疗,比较两组治疗效果。结果冲击组儿童难治性肺炎支原体肺炎疗效高于常规组(P<0.05)。冲击组咳嗽、发热消失时间以及肺部体征消失时间和常规组差异存在显著统计学意义(P<0.05)。冲击组炎性因子肿瘤坏死因子-α、白介素-6、白介素-10、超敏c反应蛋白均低于常规组(P<0.05)。冲击组的不良反应发生率和常规组差异无显著统计学意义(P>0.05)。结论常规抗感染、化痰止咳等方法治疗联合甲基泼尼松龙冲击治疗儿童难治性肺炎支原体肺炎效果良好,可有效控制炎性指标,改善临床症状体征,且未增加副作用。Objective To explore the impact of Clinical Pulse Methylprednisolone Therapy(PMT)on children’s symptoms and physical signs and inflammatory factors of Refractory Mycoplasma Pneumoniae Pneumonia(RMPP).Methods A total of 100 children with RMPP treated in the Department of Pediatrics of two hospitals from January 2019 to December2019 were averagely randomized into the control group and the experimental group.The control group underwent conventional treatment(using drugs for anti-infection,phlegm resolving,cough relieving,etc.),while the experimental group underwent conventional treatment combined with PMT.The results were compared between the groups.Results The efficacy of the experimental group was better than that of the control group(P<0.05).The difference of time for disappearance of cough,fever and lung signs between the two groups was statistically significant(P<0.05).The levels of inflammatory factors such as tumor necrosis factor-α,interleukin-6,interleukin-10 and hypersensitive C-reactive protein in the experimental group were all lower than those in the control group(P<0.05).Besides,there was no significant difference between the two groups in the incidence of adverse reaction(P>0.05).Conclusion Conventional treatment combined with PMT demonstrates satisfactory effect on children with RMPP.It can control inflammatory indicators effectively and improve clinical symptoms without increasing side effects.

关 键 词：甲基泼尼松龙冲击 儿童难治性肺炎支原体肺炎 症状体征 炎性因子 影响 

分 类 号：R725.6[医药卫生—儿科] R720.5[医药卫生—临床医学]