动物脂肪组织相关miRNAs的研究进展  

Advances in Animal Adipose Tissue-related miRNAs

作　　者：张琦悦 何春 孙浩玮 庞卫军[1] ZHANG Qiyue;HE Chun;SUN Haowei;PANG Weijun(Northwest Agriculture and Forestry University,Shaanxi Yangling 712100,China)

机构地区：[1]西北农林科技大学动物科技学院,陕西杨凌712100

出　　处：《中国畜牧杂志》2020年第7期46-51,共6页Chinese Journal of Animal Science

基　　金：国家重点基础研究发展计划项目(973计划)(2015CB 943102);国家自然科学基金项目(31572366、31872979);西北农林科技大学2019年大学生创新创业训练计划项目(201910712102)。

摘　　要：脂肪生成是一个复杂而精密的生物学过程,受多种信号通路、转录因子及小分子物质调控。miRNA是动物脂肪发育过程中的一类潜在的调控因子,是长度仅为18~24 nt的单链小分子RNA,可通过碱基互补配对与脂肪相关基因的mRNA 3’-UTR结合发挥调控作用。本文主要阐述动物脂肪相关的miRNAs的生物学本质及其在调控脂肪细胞分化、脂质代谢方面的相关研究进展,并引入可以促进组织、器官间信息交流的循环miRNA这一新发现,为通过调控miRNA进行家畜肉品质改良提供依据。Adipogenesis is a complex and precise biological process,which is regulated by a variety of signaling pathways,transcription factors and small molecules.miRNAs are a kind of potential regulatory factors in the development of animal adipose.They are single-stranded small-molecules with length of only 18-24 nt,which can play a regulatory role by binding to miRNA 3'-UTR of adipose-related genes.This article starts with clarifying the biological nature of adipose-related miRNAs,and then summarizes the related research progresses in miRNAs-regulated adipocyte differentiation and lipid metabolism,and introduces the new discovery of circulating miRNAs,which can promote information communication between tissues or organs.The purpose of this article is to provide evidences for improving meat quality through the regulation of miRNAs.

关 键 词：MIRNA 脂肪细胞分化 脂质代谢 循环miRNA 

分 类 号：S813[农业科学—畜牧学]