六郁同治法组方胰岛康Ⅱ号治疗肥胖型糖尿病前期临床观察  

Clinical Observation on Liuyu Tongzhi Method Formulated Yidao KangⅡin the Treatment of Obesity Pre-diabetes

作　　者：莫小书 周月红[1] 廖尚上 荣三群 姜艳 刘敏 胡文孝 常九州 MO Xiaoshu;ZHOU Yuehong;LIAO Shangshang;RONG Sanqun;JIANG Yan;LIU Min;HU Wenxiao;CHANG Jiuzhou(Department of Endocrinology,Liuyang Hospital of Traditional Chinese Medicine,Hunan Province,Liuyang 410300,China)

机构地区：[1]浏阳市中医医院内分泌科,湖南浏阳410300

出　　处：《中国中医药现代远程教育》2020年第12期61-64,共4页Chinese Medicine Modern Distance Education of China

基　　金：湖南省长沙市卫生计生委科研计划课题项目【No.18】。

摘　　要：目的观察六郁同治法组方胰岛康Ⅱ号治疗肥胖型糖尿病前期的临床疗效。方法选取符合纳入标准的144例肥胖型糖尿病前期患者,按随机数字表法分为治疗组与对照组各72例,对照组采用糖尿病前期常规疗法,治疗组在对照组的基础上予以胰岛康Ⅱ号胶囊治疗,疗程为12周,观察2组患者的临床疗效、中医证候积分、血糖转归情况、体质量指数(BMI)、糖化血红蛋白(Hb A1c)、空腹血糖(FBG)、OGTT试验2 h血糖(OGTT2h PBG)、血脂常规。结果治疗组总有效率达88.89%,优于对照组的64.44%(P<0.05);治疗组血糖恢复正常率优于对照组(P<0.05),治疗组血糖维持不变率及糖尿病发生率均低于对照组(P<0.05);治疗组在改善中医证候积分优于对照组(P<0.05);治疗组的BMI、FBG、OGTT2h PBG及Hb A1c水平较对照组下降更明显(P<0.05);治疗组TC、TG、LDL-C和HDL-C的改善情况优于对照组(P<0.05)。结论"六郁同治法"组方胰岛康Ⅱ号治疗肥胖型糖尿病前期的疗效确切,能够纠正患者的糖、脂代谢紊乱,减少或延缓糖尿病的发生。Objective To observe Liuyu Tongzhi method formulated Yidao Kang Ⅱ in the treatment of obesity pre-diabetes. Methods144 cases included in the standard obesity pre-diabetes, according to random number table method were selected and divided into treatment group and control group, with 72 cases in each group. The control group received routine pre-diabetes therapy, and the treatment group received Yidao Kang Ⅱ capsule on the basis of the control group. The treatment continued for 12 weeks. Clinical efficacy, TCM syndrome score, blood glucose outcome, body mass index(BMI), glycosylated hemoglobin(HbA1 c), fasting blood glucose(FBG), 2-hour OGTT test blood glucose(OGTT2 hPBG) and blood lipid routine were observed. Results The total effective rate of the treatment group was 88.89%, which was better than 64.44% of the control group(P<0.05). The blood glucose recovery rate in the treatment group was better than that in the control group( P <0.05), and the blood glucose maintenance rate and diabetes incidence rate in the treatment group were lower than those in the control group( P<0.05). The improvement of TCM syndrome score in the treatment group was better than that in the control group( P<0.05). After treatment, the levels of BMI, FBG, OGTT2 hPBG and HbA1 c in the treatment group were significantly lower than those in the control group( P<0.05). The improvement of TC, TG, LDL-C and HDL-C in the treatment group was better than that in the control group( P<0.05). Conclusion Liuyu Tongzhi method formulated Yidao Kang Ⅱ has curative effect for the treatment of obesity pre-diabetes, able to correct the patient ’s sugar, lipid metabolism disorders, reduce or delay the onset of diabetes.

关 键 词：六郁同治法 脾瘅 湿热蕴脾证 肥胖 糖尿病 中医药疗法 消渴 

分 类 号：R259[医药卫生—中西医结合]