基于海马糖皮质激素受体蛋白表达的阿尔茨海默病痰浊证发病机制研究进展  

Research progress on pathogenesis of Alzheimer’s disease with syndrome of turbid phlegm based on expression of glucocorticoid receptor protein in hippocampus

作　　者：刘宁 秦亚莉 韩诚 贺文彬 LIU Ning;QIN Ya-li;HAN Cheng;HE Wen-bin(The Hospital of Shanxi University of Chinese Medcine,Taiyuan 030024,China;Shanxi University of Chinese Medcine,Jinzhong 030619,China)

机构地区：[1]山西中医药大学附属医院,太原030024 [2]山西中医药大学,晋中030619 [3]山西中医药大学实验中心,晋中030619

出　　处：《中华中医药杂志》2020年第7期3536-3539,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81703959,No.81573853)。

摘　　要：阿尔茨海默病研究方向一直局限于以病理特征为导向的系列研究,如脑内β淀粉样蛋白异常聚集形成的老年斑、Tau蛋白过度磷酸化导致的神经元内纤维缠结、脑区不同程度萎缩等,国内外以清除Aβ沉积为策略研发的药物相继失败,笔者经过反思并将研究目标前置,从海马糖皮质激素受体蛋白表达及相关通路入手,选取该病中医典型证候痰浊证为研究对象,进行阿尔茨海默病痰浊证机制研究。文章旨在通过文献研究寻找依据,为下一步实验研究的顺利开展提供充分依据。Alzheimer’s disease research direction has been limited to a series of pathological-oriented studies,such as senile plaques formed by abnormal aggregation of beta-amyloid protein in the brain,intraneuronal fibre tangles caused by Tau protein overphosphorylation,atrophy of brain regions in varying degrees,etc..Drugs developed at home and abroad with the strategy of eliminating the deposition of Abeta have failed successively.After reflection,it will put forward our research objectives.By focusing on the expression of glucocorticoid receptor protein in hippocampus and its related pathways,the syndrome of phlegm turbidity,a typical TCM syndrome of Alzheimer’s disease,was selected as the research object to study the mechanism of Alzheimer’s disease with syndrome of phlegm turbidity.The purpose of this paper is to find a basis through literature research,and provide a sufficient basis for the smooth development of the next experimental research.

关 键 词：海马糖皮质激素受体 表达失衡 阿尔茨海默病 痰浊证 相关性 文献研究 

分 类 号：R277.7[医药卫生—中医学]