基于网络药理学的蒙药述达格-4抗癌作用机制研究  

Study on anti-cancer mechanism of Mongolian medicine Shudage-4 based on network pharmacology

作　　者：朱小玲 白凤 李斌鑫 许佳 董玉 ZHU Xiao-ling;BAI Feng;LI Bin-xin;XU Jia;DONG Yu(Department of Pharmacy,Inner Mongolia International Mongolian Hospital,Hohhot 010065,China;College of Pharmacy,Inner Mongolia Medical University,Hohhot 010110,China;School of Foreign Languages,Inner Mongolia Medical University,Hohhot 010110,China)

机构地区：[1]内蒙古自治区国际蒙医医院药学部,呼和浩特010065 [2]内蒙古医科大学药学院,呼和浩特010110 [3]内蒙古医科大学外国语学院,呼和浩特010110

出　　处：《中华中医药杂志》2020年第7期3618-3622,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金项目(No.81260680);内蒙古自治区科技创新引导奖励基金项目(No.1639003);内蒙古自治区草原英才创新团队项目(2012-2018);内蒙古自治区自然科学基金重大项目(No.2019ZD16)。

摘　　要：目的:对蒙药述达格-4进行网络药理学的研究,探索其抗胃癌的活性成分和作用靶点。方法:应用文献检索和中药系统药理学数据库和分析平台(TCMSP)筛选述达格-4中的化合物,从SuperTarget、DrugBank、BindingDB、Therapeutic Targets Database(TTD)等数据库收集述达格-4中化合物对应的靶点和胃癌相关靶点,采用Cytoscape3.1.0软件建立化合物-靶点-胃癌的网络。结果:筛选得到述达格-4中16个化合物和19个胃癌相关靶点。证明了蒙药述格达-4"多成分、多靶点"整体作用的特点。结论:本研究为阐明蒙药述达格-4抗胃癌的药效物质及作用机制奠定基础。从述达格-4中筛选得到16个化合物可作为先导化合物,为寻找抗胃癌新药做贡献。Objective:The study on network pharmacology of Mongolian medicine Shudage-4 was carried out to explore its anti-gastric carcinoma active ingredients and targets.Methods:Screening the chemical constituents of Shudage-4 by literature search and TCMSP database.Through SuperTarget,DrugBank,BindingDB,Therapeutic Targets Database(TTD)and other database,the corresponding targets of the chemical compound of Shudage-4 and the targets related to gastric cancer were collected and by means of Cytoscape3.1.0 software,the network model of compound-targets-gastric carcinoma was established.Results:A total of 16 kinds of compounds and 19 gastric carcinoma-related targets were attained through screening.Network models,which was a clear evidence to prove the characteristics of overall effect of Mongolian Shudage-4 in terms of multi-component and multitarget.Conclusion:This research,which provides a clear base on explaining the active substances and mechanism of anti-gastric carcinoma effect of Mongolian medicine Shudage-4.Those 16 kinds of compound screened from Shudage-4 can be considered as lead compound to make contribution to finding new anti-gastric carcinoma medicine.

关 键 词：网络药理学 述达格-4 多成分-多靶点 作用机制 

分 类 号：R29[医药卫生—民族医学]