心理应激因素与更年期综合征的相关性研究  

Study on the correlation between psychological stress factors and menopausal syndrome

作　　者：王铁枫[1] 刘雁峰[2] 吴杨乔 石玥 赵青竹 WANG Tie-feng;LIU Yan-feng;WU Yang-qiao;SHI Yue;ZHAO Qing-zhu(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;The First People’s Hospital of Fuyang Hangzhou,Hangzhou 311400,China;Beijing Haidian Maternal&Child Health Hospital,Beijing 100080,China;The First Affiliated Hospital of Henan University,Kaifeng 475000,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学东直门医院妇科,北京100700 [3]杭州市富阳区第一人民医院,杭州311400 [4]北京市海淀区妇幼保健院,北京100080 [5]河南大学第一附属医院,开封475000

出　　处：《中华中医药杂志》2020年第7期3665-3669,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：北京中医药大学教学名师工作坊(No.MSGZF-201905);首都卫生发展科研专项项目(No.首发2020-2-4194)。

摘　　要：目的:探讨心理应激因素与更年期综合征(MPS)及其中医证候的相关性。方法:以118例符合条件的MPS患者为研究对象,填写改良Kupperman Index(KI)调查表、团体用社会心理应激调查表(PSSG)和中医证候调查表,检测围绝经期组患者的血清雌二醇(E2)、促卵泡生成素(FSH)水平,根据年龄、症状和血清FS H水平分为围绝经期和绝经后期两组。结果:118例M PS患者中,失眠,潮热、出汗和疲乏无力是出现频次最多的3个症状;心肾不交证和肾阴阳两虚证患者的KI评分和心理应激程度总分(TS)均显著高于其他3个证候(P<0.05);被研究人群的消极情绪体验显著多于积极情绪体验(P<0.05),而积极应对显著高于消极应对(P<0.05);绝经后期患者的TS显著高于围绝经期患者(P<0.05);118例MPS患者的TS和KI呈正相关(P<0.05);围绝经期患者的血清E2水平与TS和KI呈负相关(P<0.05),血清FSH水平与KI呈正相关(P<0.05)。结论:MPS是一种应激相关性疾病;对绝经前女性采取早期心理干预及中医辨证施护等措施,有助于预防或减轻其MPS的发生。Objective:To investigate the correlation between psychological stress factors and menopausal syndrome(MPS)and its traditional Chinese medicine syndromes.Methods:A total of 118 qualified MPS patients,who were required to fill in the modified Kupperman Index(KI)questionnaire,psychosocial stress survey for groups(PSSG)and traditional Chinese medicine syndrome questionnaire and be examined with serum estradiol(E2)and follicle-stimulating hormone(FSH)level,were divided into perimenopausal and postmenopausal groups according to age,symptoms and serum FSH levels.Results:Among the 118 MPS patients,insomnia,hot sweating and fatigue were the three most frequent symptoms.KI score and total score of psychological stress(TS)of patients with heart-kidney non-interaction syndrome and syndrome of deficiency of both yin and yang of kidney were significantly higher than the other three syndromes(P<0.05).The negative emotional experience of the studied population was significantly more than the positive emotional experience(P<0.05),and the positive response was significantly higher than the negative response(P<0.05).TS in postmenopausal patients is significantly higher than in perimenopausal patients(P<0.05).TS and KI were positively correlated in the 118 MPS patients(P<0.05).In perimenopausal patients,E2 level was negatively correlated with TS and KI(P<0.05),while serum FSH level was positively correlated with KI(P<0.05).Conclusion:MPS is a stress-related disease.Early psychological intervention and traditional Chinese medicine syndrome differential nursing are helpful to prevent or reduce MPS in premenopausal women.

关 键 词：更年期综合征 心理应激 中医证候 流行病学调查 雌二醇 促卵泡生成素 

分 类 号：R711.75[医药卫生—妇产科学]