清瘀明目方熏蒸对消渴目病患者视网膜动脉血流动力学及报告结局的影响  

Effects of fumigation with Qingyu Mingmu prescription on retinal blood flow and patient-reported outcome in patients with diabetic retinopathy

作　　者：万燕萍[1] 倪冬梅[2] 芦笑令 WANG Yanping;NI Dongmei;LU Xiaoling(Department of Endocrinology,Changzhou Hospital of Traditional Chinese Medicine,Changzhou,Jiangsu,213000;Department of Ophthalmology,Changzhou Hospital of Traditional Chinese Medicine,Changzhou,Jiangsu,213000)

机构地区：[1]江苏省常州市中医医院内分泌科,江苏常州213000 [2]江苏省常州市中医医院眼科,江苏常州213000

出　　处：《中西医结合护理（中英文）》2020年第5期45-49,共5页Journal of Clinical Nursing in Practice

基　　金：科技部创新医疗器械产品应用示范工程(国科办农2017-57);江苏省常州市第41批科技计划项目(2016373)。

摘　　要：目的探讨清瘀明目方熏蒸对消渴目病患者视网膜动脉血流动力学及报告结局的影响。方法选取2018年7月-2019年6月内分泌科收治的消渴目病患者60例(120眼),随机分为熏蒸组30例(60眼)与对照组30例(60眼)。对照组行穴位保健操,熏蒸组在对照组基础上开展清瘀明目方眼部熏蒸。观察2组中医证候疗效、视网膜动脉血液流动力学指标变化以及消渴目病患者报告结局(PRO)。结果对照组1例患者(2眼)脱落,未能完成随访。熏蒸组中医症候疗效总有效率高于对照组,差异有统计学意义(P<0.05)。干预12周后,2组视网膜中央动脉血流动力学指标均有改善,且熏蒸组患者视网膜动脉血液流动力学指标改善优于对照组,差异有统计学意义(P<0.05)。干预12周后,2组PRO各维度评分均降低,且熏蒸组PRO各维度评分及总分低于对照组,差异有统计学意义(P<0.05)。结论清瘀明目方熏蒸可有效提高消渴目病患者的中医证候疗效,改善眼底循环障碍,减轻疾病对患者生理、心理、社会等方面的影响,有利于改善其生存质量。Objective To observe the effect of fumigation with Qingyu Mingmu prescription on the retinal blood flow and patient-reported outcome in patients with diabetic retinopathy. Methods Totally 60 patients(120 eyes)with diabetic retinopathy were randomly divided into the observation group and the control group, with 30 cases in each group. All patients received acupoint exercises during the treatment, and those in the observation group received fumigation with Qingyu Mingmu prescription. After 12 weeks, the therapeutic effects of TCM syndromes in the two groups were evaluated, and the changes of retinal arterial blood flow and patient-reported outcome(PRO) in the two groups before and after intervention were observed. Results There was 1 patient(2 eyes) lost to follow-up. After 12 weeks of intervention, the total response rate of TCM syndrome relief in the observation group was significantly higher than that in the control group,(P<0.05). The main indicators of retinal artery blood flow such as end diastolic volume(EDV), systolic peak blood flow velocity(PSV), pulse index(PI) and blood flow resistance index(RI)in the observation group were better than those in the control group, with statistically significant differences(P<0.05). The factor scores of specific symptom dimension, syndrome effect dimension, psychological dimension, social dimension and total score of PRO were lower in the observation group than those in the control group, with statistically significant differences(P<0.05). Conclusion The fumigation with Qingyu Mingmu prescription is potentially effective relieve the syndromes of patients with diabetic retinopathy, improve retinal circulation, reduce the physiological, psychological and social effects of diseases on patients and improve the patients’ quality of life.

关 键 词：清瘀明目方 中药熏蒸 消渴目病 糖尿病 视网膜 血流动力学 中西医结合护理 

分 类 号：R473.5[医药卫生—护理学]