2019冠状病毒病749例患者中医药治疗的真实世界临床研究  

Clinical efficacy of traditional Chinese medicine among 749 patients with COVID-19:A real-world study

作　　者：李昊[1] 吕文亮[1] 孙易娜[1] 肖勇[1] 杨旻[1] 杨海军[1] 高清华[1] 杨忠奇[2] 吕文良[3] 凌瑞杰 寿折星[5] 胡家才[6] 赵新芳[7] 马永刚[6] 刘明瑜 罗正武 程冰洁 刘林[1] 沈峰[1] 张思依 曾江琴[1] 向阳 黄超群[1] 杨琼[1] 丁辛 秦泠曦 王仁礼 LI Hao;LYU Wen-liang;SUN Yi-na;XIAO Yong;YANG Min;YANG Hai-jun;GAO Qing-hua;YANG Zhong-qi;LYU Wen-liang;LING Rui-jie;SHOU Zhe-xing;HU Jia-cai;ZHAO Xin-fang;MA Yong-gang;LIU Ming-yu;LUO Zheng-wu;CHENG Bing-jie;LIU Lin;SHEN Feng;ZHANG Si-yi;ZENG Jiang-qin;XIANG Yang;HUANG Chao-qun;YANG Qiong;DING Xin;QIN Ling-xi;WANG Ren-li(Hubei University of Chinese Medicine,Wuhan 430061,China;The First Affiliated Hespital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Wuhan 430015,China;Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China;Renmin Hospital of Wuhan University,Wuhan 430060,China;First Affiliated Hospital of Shihezi University Medical College,Shihezi 832008,China;The Ninth Hospital of Wuhan,Wuhan 430081,China;Wuhan Xinzhou District People's Hospital,Wuhan 431400,China;The Third People'Hospital of Hubei Province,Wuhan 430033,China)

机构地区：[1]湖北中医药大学,武汉430061 [2]广州中医药大学第一附属医院,广州510405 [3]中国中医科学院广安门医院,北京100053 [4]湖北省中西医结合医院,武汉430015 [5]华中科技大学同济医学院附属协和医院,武汉430022 [6]武汉大学人民医院,武汉430060 [7]石河子大学医学院第一附属医院,新疆石河子832008 [8]武汉市第九医院,武汉430081 [9]武汉市新洲区人民医院,武汉431400 [10]湖北省第三人民医院,武汉430033

出　　处：《中华中医药杂志》2020年第6期3194-3198,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家重点研发计划“公共安全风险防控与应急技术装备”重点专项(No.2020YFC0845300)。

摘　　要：目的:观察中医药治疗2019冠状病毒病(COVID-19)轻型、普通型的临床疗效。方法:收集2020年2月5日至3月10日武汉地区8家方舱医院中,采用中医药治疗或中西医结合治疗的轻型、普通型COVID-19患者749例,分析重型/危重型转化率、住院(在舱)天数、核酸转阴天数、用药天数、临床症状改善情况及肺部CT影像学改善情况,并对中医组与中西医组的疗效进行比较。结果:中医组与中西医组重型/危重型转化率均为0,差异无统计学意义;中西医组住院(在舱)天数、核酸转阴天数、用药天数较中医组长(P<0.01,P<0.05);中西医组咯痰、咽痛、肌肉酸痛消失时间较中医组长(P<0.01,P<0.05);中医组肺部CT影像学改善情况优于中西医组(P<0.05)。结论:中医药能减少轻型、普通型COVID-19患者住院(在舱)天数、核酸转阴天数、用药天数、部分主要症状消失时间,有效改善肺部CT影像学结局。Objective:To observe the clinical efficacy of traditional Chinese medicine(TCM)in the treatment of mild and common patients with Corona Virus Disease 2019(COVID-19).Methods:A total of 749 mild and common COVID-19 patients hospitalized were collected at 8 Fangcang hospitals in Wuhan from February 5th to March 10th,2020.After treatment with TCM or integrated traditional Chinese and western medicine(TCM-WM),to analyze severe/critical conversion rate,hospital days(days in Fangcang hospitals),negative conversion time of virus nucleic acid,days of medication,clinical symptoms improvement and lung computed tomography(CT)imaging improvement,and compare the efficacy of the TCM group and the TCM-WM group.Results:The severe/critical conversion rate of the TCM group and the TCM-WM group was 0,and there was no significant difference.The hospital days(days in Fangcang hospitals),negative conversion time of virus nucleic acid,days of medication in the TCM-WM group were longer than those in the TCM group(P<0.01,P<0.05).The disappearance time of expectoration,pharyngodynia,muscle soreness in the TCM-WM group were longer than that in the TCM group(P<0.01,P<0.05).The lung CT imaging improvement in the TCM group was better than that in the TCM-WM group(P<0.05).Conclusion:The application of TCM can reduce the hospital days,negative conversion time of virus nucleic acid,days of medication,some of main clinical symptom disappearance time for patients with mild and common COVID-19 and effectively improve the results of chest CT.

关 键 词：2019冠状病毒病 新型冠状病毒肺炎 真实世界研究 连花清瘟胶囊 瘟疫 传染病 清肺排毒汤 

分 类 号：R259[医药卫生—中西医结合]