防感散治疗110例肺脾气虚型小儿反复上呼吸道感染的临床研究  

Clinical study on 110 cases of recurrent upper respiratory tract infection children with qi deficiency of lung and spleen treated by Fanggan Powder

作　　者：张田芳 高文杰[2] 安家盛 普微 刘社涛 孙鑫 张永辉 孙艳红 高绍芳[1] ZHANG Tian-fang;GAO Wen-jie;AN Jia-sheng;PU Wei;LIU She-tao;SUN Xin;ZHANG Yong-hui;SUN Yan-hong;GAO Shao-fang(Hebei University of Chinese Medicine,Shijiazhuang 050200,China;Hebei Children's Hospital,Shijiazhuang 050031,China;Shijiazhuang Traditional Chinese Medicine Hospital,Shijiazhuang 050000,China;Wuji County Hospital,Wuji County 052460,China)

机构地区：[1]河北中医学院,石家庄050200 [2]河北省儿童医院,石家庄050031 [3]石家庄市中医院,石家庄050000 [4]无极县医院,河北无极县052460

出　　处：《中华中医药杂志》2020年第6期3214-3217,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河北省科技支撑计划项目(No.16277755D)。

摘　　要：目的:探究防感散治疗肺脾气虚型小儿反复上呼吸道感染的有效性和对免疫水平的影响。方法:选取2017年12月至2018年12月就诊于河北省儿童医院儿科门诊的110例符合纳入标准的肺脾气虚型反复上呼吸道感染患儿按照1∶1比例随机分入对照组和观察组。在本病缓解期两组均治疗2个月,观察组采用防感散颗粒进行冲服,对照组采用脾氨肽口服冻干粉治疗。分别于用药前后,记录两组患儿的发病次数、病程,中医证候积分,并检测T细胞亚群及血清免疫球蛋白的指标。结果:治疗2个月后,两组IgA、IgG、IgM、CD3^+、CD4^+值较治疗前升高(P<0.01),且观察组高于对照组(P<0.01);两组CD8^+值降低(P<0.01),且观察组低于对照组(P<0.05);两组中医证候积分均有不同程度下降(P<0.01),且观察组低于对照组(P<0.05)。两组均有明显疗效且观察组总体疗效优于对照组(P<0.05,P<0.01)。结论:缓解期采用防感散颗粒治疗,能改善脾肺气虚型小儿反复上呼吸道感染症状及免疫功能。Objective:To explore the effectiveness and effect of Fanggan Powder on recurrent upper respiratory tract infection children with qi deficiency of lung and spleen.Methods:From December 2017 to December 2018,a total of 110 cases of recurrent upper respiratory tract infection children with qi deficiency of lung and spleen from Pediatrics Department of Hebei Children’s Hospital that met the inclusion criteria were randomly divided into a control group and an observation group according to a 1:1 ratio.Both groups were treated for 2 months during the remission period of the disease.The observation group was treated with Fanggan Powder,and the control group was treated with Spleen Aminopeptide Oral Lyophilized Powder.Before and after medication,record the number of illnesses,course of disease,TCM syndrome scores,and detect T cell subsets and serum immunoglobulin indexes in the two groups of patients.Results:At the end of two months of treatment,the IgA,IgG,IgM,CD3^+and CD4^+values of the two groups were higher than before treatment(P<0.05),and the observation group were higher than the control group(P<0.01);the CD8^+value and TCM syndrome scores of the two groups decreased than before treatment(P<0.01),and the observation group was lower than the control group(P<0.01,P<0.05).Both groups had significant effects and the observation group overall efficacy was better than the control group(P<0.05,P<0.01).Conclusion:The use of Fanggan Powder in the remission period can improve the symptoms and immune function of children.

关 键 词：小儿反复上呼吸道感染 脾氨肽 防感散 肺脾气虚 

分 类 号：R272[医药卫生—中医儿科学]