果酸换肤联合阿达帕林凝胶外用治疗轻中度痤疮的临床效果及安全性分析  

Clinical Efficacy and Safety Analysis of Fruit Acid Peeling Combined with Adapalene Gel for External Treatment of Mild to Moderate Acne

作　　者：林辉 LIN Hui(Putian Dermatology Prevention Hospital,Putian 351100,China)

机构地区：[1]莆田市皮肤病防治院,福建莆田351100

出　　处：《中外医学研究》2020年第16期23-25,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探析轻中度痤疮患者应用果酸换肤联合阿达帕林凝胶外用治疗的临床效果及安全性。方法:将2018年1月-2019年6月在笔者所在医院治疗的120例轻中度痤疮患者选为观察对象,按照随机原则分成对照组与试验组,各60例。对照组单独予以阿达帕林凝胶外用治疗,试验组予以果酸换肤联合阿达帕林凝胶外用治疗,比较两组临床疗效、治疗前后皮损计数、不良反应发生率。结果:试验组临床总有效率为96.67%,高于对照组的81.67%,差异有统计学意义(P<0.05)。治疗后两组粉刺、脓疱、丘疹皮损计数均低于治疗前,且试验组各指标计数均低于对照组,差异均有统计学意义(P<0.05)。试验组不良反应发生率为5.00%,对照组为3.33%,差异无统计学意义(P>0.05)。结论:轻中度痤疮患者应用果酸换肤联合阿达帕林凝胶外用治疗的临床效果更加确切,能够有效减轻患者皮损程度,且不会明显增加不良反应,具有安全、可靠的特点。Objective:To analyze the clinical efficacy and safety of patients with mild to moderate acne treated with Fruit Acid peeling and Adapalene Gel.Method:A total of 120 mild to moderate acne patients treated in our hospital from January 2018 to June 2019 were selected as observation objects,and were divided into the control group and the experimental group according to the random principle,with 60 cases in each group.Patients in the control group were given external treatment with Adapalene Gel alone.Patients in the experimental group were treated with Fruit Acid peeling and external treatment with Adapalene Gel.The clinical effect,the number of skin lesions before and after treatment and the incidence of adverse reactions were compared between the two groups.Result:The total clinical effective rate in the experimental group was 96.67%,which was higher than 81.67% in the control group,the difference was statistically significant (P<0.05).After treatment,the skin lesions of acne,pustules and papules in the two groups were lower than those before treatment,and the indexes in the experimental group was lower than that in the control group,the differences were statistically significant (P<0.05).The incidence of adverse reactions in the experimental group was 5.00%,and which in the control group was 3.33%,the difference was not statistically significant (P>0.05).Conclusion:The clinical effect of the application of Fruit Acid peeling and Adapalene Gel external treatment in patients with mild to moderate acne is more precise,which can effectively reduce the degree of skin lesions without significantly increasing adverse reactions.It is safe and reliable.

关 键 词：痤疮 果酸换肤 阿达帕林凝胶 临床疗效 不良反应 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]