862株铜绿假单胞菌的临床分布及耐药分析  

Clinical Distribution and Drug Resistance Analysis of 862 Strains of Pseudomonas Aeruginosa

作　　者：陶敏 廖娟[1] TAO Min;LIAO Juan(People’s Hospital Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350004,China;不详)

机构地区：[1]福建中医药大学附属人民医院,福建福州350004

出　　处：《中外医学研究》2020年第16期66-69,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究铜绿假单胞菌(pseudomonas aeruginosa,PA)的临床分布和耐药情况以指导临床合理用药。方法:用WHONET 5.6软件对笔者所在医院2013年1月-2018年12月检出的PA进行回顾性分析。结果:共分离出862株PA,其中2013年检出率最低为3.6%(132/3 656),2018年检出率最高为6.8%(177/2 593)。PA主要分布于疮疡科(12.4%),其次为肺病科(12.2%)、重症医学科(11.9%)、心胸外科(10.0%)、肛肠科(8.2%)。PA主要来源于痰液(52.8%),其次为脓液(15.3%)、分泌物(13.2%)。PA对常见抗菌药物的耐药率普遍低于21.0%,对亚胺培南的耐药率最高为20.9%,对阿米卡星的耐药率最低为4.5%。结论:在笔者所在医院中,PA检出率呈上升趋势,以脓液及分泌物中PA的上升趋势最显著。此外,PA对常见抗菌药物的耐药率存在上升趋势。掌握PA的临床分布和耐药性情况,可以为临床防治PA感染提供依据。Objective:To explore the clinical distribution and drug resistance of pseudomonas aeruginosa (PA) to guide clinical rational drug use.Method:The PA detected in our hospital from January 2013 to December 2018 was retrospectively analyzed with WHONET 5.6 software.Result:A total of 862 strains of PA were isolated,with the lowest detection rate of 3.6% (132/3 656) in 2013 and the highest detection rate of 6.8% (177/2 593) in 2018.PA was mainly distributed in the department of ulcer selection (12.4%),followed by the department of pulmonary disease (12.2%),the department of critical care medicine (11.9%),the department of cardiothoracic surgery (10.0%),and the department of anorectal surgery (8.2%).PA was mainly derived from sputum (52.8%),followed by pus (15.3%) and secretions (13.2%).The drug resistance rate of PA to common antibacterial agents was generally less than 21.0%,the highest drug resistance rate to Imipenem was 20.9%,and the lowest drug resistance rate to Amikacin was 4.5%.Conclusion:The detection rate of PA in our hospital has a rising trend,with the most significant rising trend of PA in pus and secretions.In addition,the drug resistance rate of PA to common antibacterial drugs increased.Understanding the clinical distribution and drug resistance of PA can provide evidence for clinical prevention and treatment of PA infection.

关 键 词：铜绿假单胞菌 临床分布 耐药 

分 类 号：R446.5[医药卫生—诊断学]