绒毛染色体异常及其环境因素与习惯性流产的关系  

The Relationship between Chromosomal Abnormality of Villi and Its Environmental Factors and Habitual Abortion

作　　者：宋娜 苏淑英 SONG Na;SU Shuying(Family Planning Service Center of Dayawan Economic and Technological Development Zone of Huizhou,Huizhou 516082,China;不详)

机构地区：[1]惠州大亚湾经济技术开发区计划生育服务中心,广东惠州516082

出　　处：《中外医学研究》2020年第19期155-157,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

基　　金：广东省深圳大鹏新区产业发展专项医疗教育环保科研项目(YL20170204)。

摘　　要：目的:观察绒毛染色体异常及其环境因素与习惯性流产的相关性。方法:选取2017年6月-2018年6月在优质服务集中活动月因习惯性流产到计划生育门诊接受治疗患者160例,将其作为观察组,并将同期计划生育门诊100例人工流产患者作为对照组,分析两组绒毛细胞染色体情况,询问并记录患者相关资料。结果:观察组绒毛染色体异常率为53.13%(85/160),高于对照组的5.00%(5/100),差异有统计学意义(P<0.05);调查患者各项环境,结果显示观察组被动吸烟、饮酒及电视电脑辐射>5 h/d、接触有害化学物质、接触放射线分别占56.25%(90/160)、7.50%(12/160)、28.13%(45/160)、47.50%(76/160)、35.63%(57/160),除饮酒因素外,其余环境因素占比均高于对照组(P<0.05),差异均有统计学意义(P<0.05);多因素非条件Logistic回归分析发现,习惯性流产与被动吸烟、电视电脑辐射>5 h/d、接触有害化学物质及接触放射线密切相关(P<0.05)。结论:绒毛染色体异常是习惯性流产的主要因素,被动吸烟、长时间接触电脑、电视、接触有害化学物质、放射线等是习惯性流产高危因素,应给予高度重视。Objective:To observe the relationship between chromosomal abnormality of villi and habitual abortion.Method:From June 2017 to June 2018,160 patients who received treatment in the family planning clinic due to habitual abortion in the month of intensive activities of quality services were selected,and were taken as the observation group,and 100 patients with induced abortion in the family planning clinic at the same period were taken as the control group.The chromosomes of villi cells in the two groups were analyzed,and the relevant information of patients was inquired and recorded.Result:The abnormal rate of villus chromosome in the observation group was 53.13%(85/160),which was higher than that in the control group 5.00%(5/100),the difference was statistically significant(P<0.05).The results showed that in the observation group,passive smoking,alcohol consumption,TV and computer radiation>5 h/d,exposure to harmful chemicals and exposure to radiation accounted for 56.25%(90/160),7.50%(12/160),28.13%(45/160),47.50%(76/160)and 35.63%(57/160),respectively.Except for drinking,the proportions of other environmental factors in the observation group were higher than those in control group,the differences were statistically significant(P<0.05).Multivariate unconditional logistic regression analysis showed that habitual abortion was closely related to passive smoking,TV computer radiation>5 h/d,exposure to harmful chemicals and radiation(P<0.05).Conclusion:The chromosomal abnormality of villi is the main factor of habitual abortion.Passive smoking,long-term exposure to computer,television,exposure to harmful chemicals and radiation are the high risk factors of habitual abortion,which should be given high attention.

关 键 词：绒毛染色体 环境因素 习惯性流产 被动吸烟 电脑辐射 

分 类 号：R714.21[医药卫生—妇产科学]