2型糖尿病对骨折患者骨转换生化指标及骨密度的影响  

Effect of Type 2 Diabetes Mellitus on Bone Turnover Biochemical Index and Bone Mineral Density in Patients with Fracture

作　　者：阚卫军 刘红星 张丽萍 王苹 薛珊 胡翠芬 KAN Weijun;LIU Hongxing;ZHANG Liping;WANG Ping;XUE Shan;HU Cuifen(Shanxi Army Hospital,Taiyuan 030006,China;不详)

机构地区：[1]武警山西省总队医院,山西太原030006

出　　处：《中外医学研究》2020年第21期138-140,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:了解2型糖尿病(T2DM)患者合并骨折的骨转换状态及骨密度变化。方法:选取2016年4月-2018年5月在笔者所在医院骨科住院行手术治疗的70岁以下男性骨折患者149例,根据患者血糖情况分为非糖尿病骨折组(82例)及2型糖尿病骨折组(67例),观察两组患者部位骨密度(BMD)、血骨特异性碱性磷酸酶(BAP)及尿脱氧吡啶啉(DPD)与尿肌酐比值等指标的变化。结果:2型糖尿病骨折组TALP、BAP均低于非糖尿病骨折组,DPD/Cr高于非糖尿病骨折组,差异均有统计学意义(P<0.05);两组不同部位骨密度比较差异无统计学意义(P>0.05)。结论:2型糖尿病可影响骨质代谢,从而可能影响骨折的愈合;骨转换生化指标变化早于骨密度,较骨密度敏感,可在临床用于2型糖尿病合并骨折的诊断。Objective:To investigate the bone transition status and bone mineral density changes in patients with type 2 diabetes mellitus(T2DM)complicated with fractures.Method:A total of 149 male fracture patients under the age of 70 who underwent surgical treatment in the department of orthopedics in our hospital from April 2016 to May 2018 were selected,patients were divided into the non-diabetic fracture group(82 cases)and the type 2 diabetic fracture group(67 cases)according to their blood glucose.The changes of bone mineral density(BMD),bone specific alkaline phosphatase(BAP)and urine deoxypyridine(DPD)in the two groups were observed.Result:The TALP and BAP in the type 2 diabetic fracture group were lower than those in the non-diabetic fracture group,and DPD/Cr was higher than that in the non-diabetic fracture group,the differences were statistically significant(P<0.05).There was no significant difference in BMD between the two groups(P>0.05).Conclusion:Type 2 diabetes affect bone metabolism and may affect fracture healing.The change of biochemical index of bone transformation is earlier than BMD and more sensitive than BMD,which can be used in the diagnosis of type 2 diabetes complicated with fracture clinically.

关 键 词：2型糖尿病 骨折 骨转换 骨密度 

分 类 号：R683[医药卫生—骨科学] R587.2[医药卫生—外科学]