皮肤创面无瘢痕愈合的研究进展  

Advance research on scar-free healing of skin wounds

作　　者：张之迅 李海航 朱世辉 Zhang Zhixun;Li Haihang;Zhu Shihui(PLA 92187 Force, Changzhi 046011, China;Department of Burn Surgery, Burn Institute of PLA, First Affiliated Hospital, Naval Military Medical University, Shanghai 200433, China)

机构地区：[1]解放军92187部队医院,长治046011 [2]海军军医大学第一附属医院烧伤外科,全军烧伤研究所,上海200433

出　　处：《中华损伤与修复杂志（电子版）》2020年第4期322-325,共4页Chinese Journal of Injury Repair and Wound Healing(Electronic Edition)

基　　金：国家重点研发计划资助项目(2019YFA0110600,2019YFA0110603);军队后勤项目(AWS18C001)。

摘　　要：皮肤作为表层的防御器官,大部分动物的皮肤受损后均以瘢痕修复的形式完成创面愈合。与此相反,部分物种具有再生皮肤而不形成瘢痕组织的独特能力,甚至存在能够再生皮肤附件的哺乳动物,其主要机制与细胞因子、免疫反应和细胞外基质(ECM)重塑有关。本文分析了具有无瘢痕创面愈合再生能力的物种的最新研究进展,并对无瘢痕创面愈合特征进行综述。The skin acts as a defensive organ of the surface layer,and most animals have their wounds healed in the form of scar repair.In contrast,some species have the unique ability to regenerate skin without forming scar tissue,and even some mammals that are capable of regenerating skin attachments.The main mechanisms are related to cytokines,immune response and extracellular matrix(ECM)remodeling.This paper reviews the latest research progress of species with the ability to regenerate scar-free wound healing and reviews the characteristics of scar-free wound healing.

关 键 词：瘢痕 皮肤 细胞外基质 免疫 无瘢痕愈合 

分 类 号：R47[医药卫生—护理学]