急性淋巴细胞白血病与人类白细胞抗原相关性研究进展  

Progress of Correlation Between Acute Lymphoblastic Leukemia and Human Leukocyte Antigen

作　　者：裴永峰 余梅 PEI Yong-Feng;YU Mei(Nanning Institute of Transfusion Medicine,Nanning Blood Center,Nanning 530007,China)

机构地区：[1]南宁中心血站,南宁输血医学研究所,广西南宁530007

出　　处：《生物技术通讯》2020年第3期325-329,共5页Letters in Biotechnology

基　　金：南宁市科学研究与技术开发计划(20183203-1)。

摘　　要：急性淋巴细胞白血病(ALL)是一种常见的血液疾病,成人ALL的预后较差。ALL的发病机制尚不完全清楚,分析是由遗传、物理、化学和生物等多因素共同作用的结果,其中人类白细胞抗原(HLA)是其重要的遗传因素。国内外研究发现许多HLA基因是ALL的易感基因或保护基因,且一些HLA分子与ALL的诊断、治疗及预后关系密切。本文主要对近5年的HLA与ALL的相关性研究进行综述,为ALL的临床治疗等研究提供重要参考依据。Acute lymphoblastic leukemia(ALL) is a common blood disease, and the prognosis of adult ALL is poor. The pathogenesis of ALL is known as the result of a combination of genetic, physical, chemical, and biological factors, but it is not fully understood. Human leukocyte antigen(HLA) is an important genetic factor. Studies have found that many HLA genes are susceptible or protective genes of ALL, and some HLA molecules are closely related to the diagnosis, treatment and prognosis of acute lymphoblastic leukemia. These researches are reviewed to provide an important reference for further clinical research on ALL.

关 键 词：急性淋巴细胞白血病 人类白细胞抗原 相关性 易感基因 保护基因 

分 类 号：R392.2[医药卫生—免疫学]