自体富血小板血浆对促进腕管综合征减压术后正中神经功能恢复的随机对照临床研究  

A randomized controlled clinical study of platelet-rich autogenous plasma in promoting the recovery of median nerve function after decompression of carpal tunnel syndrome

作　　者：王辉[1] 王贺[2] 赵峰[1] 朱超华[1] 韩新生 陈丽[4] WANG Hui;WANG He;ZHAO Feng;ZHU Chao-hua;HAN Xin-sheng;CHEN Li(Department of Orthopedics, the First Hospital of Hebei Medical University, Shijiazhuang 050031, China;Department of Pathogen Biology, Hebei Medical University, Shijiazhuang 050017, China;Emergency Department, Dingxing County Hospital, Hebei Province, Baoding 072650, China;Department of Pharmacy, Baoding Fifth Hospital, Hebei Province, Dingxing 071027, China)

机构地区：[1]河北医科大学第一医院骨科,河北石家庄050031 [2]河北医科大学病原生物教研室,河北石家庄050017 [3]河北省定兴县医院急诊科,河北定兴072650 [4]河北省保定市第五医院药房,河北保定071027

出　　处：《河北医科大学学报》2020年第7期780-783,共4页Journal of Hebei Medical University

基　　金：河北省医学科学研究重点课题计划(20170510)。

摘　　要：目的研究自体富血小板血浆(platelet-rich plasma,PRP)对促进腕管综合征减压术后正中神经功能恢复的疗效。方法选取腕管综合征的患者40例,按随机数字表法随机分为对照组和PRP注射组各20例。对照组行腕管切开减压正中神经松解术;PRP注射组行腕管切开减压正中神经松解+PRP注射术。观察比较两组患者感觉、肌力及肌电图指标恢复情况。结果共有31例患者得到随访,对照组有4例患者失访,PRP注射组有5例患者失访,均随访12个月以上。2组术后1、3、6和12个月的视觉模拟疼痛量表(Visual Analogue Scales,VAS)评分、肌力分级、正中神经感觉神经传导速度(sense nerve conduction velocity,SNCV)和运动神经传导速度(motor nerve conduction velocity,MNCV)在组间、时点间、组间和时点间的交互作用差异均有统计学意义(P<0.01)。结论PRP能促进腕管综合征减压术后正中神经的感觉及运动功能的恢复。Objective To study the effect of autologous platelet-rich plasma(PRP)on the recovery of median nerve function after decompression for carpal tunnel syndrome.Methods Forty patients with carpal tunnel syndrome were selected.According to the random number table method,they were randomly divided into control group and PRP injection group with 20 cases.The control group received carpal tunnel decompression.PRP injection group received peripheral injection of PRP after carpal tunnel decompression.The recovery of sensation,muscle strength and EMG of the two groups were compared.Results Thirty-one patients were followed up,with 4 patients lost to follow-up in the control group and 5 patients lost to follow-up in the PRP injection group.Patients in both groups were followed up for more than 12 months.VAS score,muscle strength grading,median nerve SNCV and MNCV showed statistically significant differences between two groups at 1,3,6 and 12 months after surgery(P<0.01).Conclusion PRP can promote the recovery of median nerve function after carpal tunnel decompression.

关 键 词：富血小板血浆 腕管综合征 正中神经 

分 类 号：R681.7[医药卫生—骨科学]