基于网络药理学探讨蒙药锁阳促智作用的物质基础及作用靶点  

Study on the Material Basis and Targets of Mongolia Medicine Cynomorium Songaricum Rupr.for Nootropic Effect Based on Network Pharmacology

作　　者：张亚男 韩瑞兰 李丹 郝云雪 Zhang Ya’nan;Han Ruilan;Li Dan;Hao Yunxue(Department of Pharmacy,Inner Mongolia Medical University,Hohhot 010110,China)

机构地区：[1]内蒙古医科大学药学院,呼和浩特010110

出　　处：《中国药师》2020年第7期1283-1288,共6页China Pharmacist

基　　金：内蒙古自治区自然科学基金项目(编号:2013MS1223)。

摘　　要：目的:基于网络药理学,初步探讨预测锁阳乙酸乙酯部位促智作用的有效成分及作用靶点。方法:通过相关数据库、网站及软件进行靶点筛选、蛋白互作及通路富集。结果:通过对病靶和药靶的分析,得到2个共靶及3条通路。结论:蒙药锁阳可通过多成分-多靶点-多通路的调控网络发挥促智作用,对锁阳促智作用的网络药理学研究可以为蒙药对阿尔茨海默病治疗的分子机制研究提供参考。Objective:To study the main active ingredients and targets for nootropic effect of ethyl acetate part of Cynomorium songaricum Rupr.based on network pharmacology.Methods:Target screening,protein interaction and pathway enrichment were performed with the relevant databases,websites and softwares.Results:Two common targets and three pathways were obtained through the analysis of disease targets and drug targets.Conclusion:Mongolia medicine Cynomorium songaricum Rupr.can promote intelligence by the regulation network of multi-component,multi-target and multi-pathway.The study of network pharmacology on the efficacy of Cynomorium songaricum Rupr.on nootropic activity can provide reference for the study of molecular mechanism of Mongolian medicine in the treatment of alzheimer’s disease.

关 键 词：锁阳 阿尔茨海默病 促智作用 活性成分 靶点 

分 类 号：R285.5[医药卫生—中药学]