水蛭黄芪汤联合TP方案同步放化疗对局部晚期非小细胞肺癌患者DLCO、血清TGF-β1水平及复发情况的影响  

Effects of Shuizhi Huangqi Decoction Combined with TP Regimen Concurrent Chemoradiotherapy on DLCO,Serum TGF-β1 Level and Recurrence of Patients with Locally Advanced Non-small Cell Lung Cancer

作　　者：杨吉帆 李春梅[2] 黄碧有[3] 张涛[4] Yang Jifan;Li Chunmei;Huang Biyou;Zhang Tao(The First Clinical College of Chongqing Medical University,Graduate School of Oncology Professionals,Chongqing 400016,China;Department of Pediatrics,Chongqing Banan District Second People’s Hospital;Department of Oncology,the Second People's Hospital,Banan District,Chongqing;Department of Oncology,the First Affiliated Hospital of Chongqing Medical University)

机构地区：[1]重庆医科大学第一临床学院研究生院,重庆400016 [2]重庆市巴南区第二人民医院儿科 [3]重庆市巴南区第二人民医院肿瘤科 [4]重庆医科大学附属第一医院肿瘤科

出　　处：《中国药师》2020年第7期1363-1365,1400,共4页China Pharmacist

摘　　要：目的:探究水蛭黄芪汤联合TP方案同步放化疗对局部晚期非小细胞肺癌(NSCLC)患者一氧化碳弥散量占预计值百分比(DLCO)、血清血管转化生长因子(TGF-β1)水平及复发情况的影响。方法:局部晚期NSCLC患者67例,根据入院顺序分为观察组(n=34)与对照组(n=33)。对照组采用TP方案同步放化疗,观察组在对照组基础上联合水蛭黄芪汤,对比两组患者近期疗效、DLCO值、肺活量(VC)、血清TGF-β1水平、药品不良反应及复发情况。结果:观察组有效率略高于对照组,复发率则略低于对照组,但差异均无统计学意义(P>0.05)。治疗后,观察组DLCO值、VC值较治疗前显著提高,且显著高于对照组(P<0.05);血清TGF-β1水平则较前显著下降,且明显低于对照组(P<0.05)。观察组白细胞减少发生率显著低于对照组(P<0.05),两组血小板减少、恶心、呕吐发生率差异无统计学意义(P>0.05)。结论:水蛭黄芪汤联合TP方案同步放化疗治疗局部晚期NSCLC效果确切,可在一定程度上改善患者肺功能,减轻机体炎症反应与不良反应,并能够减少复发。Objective:To explore the effects of Shuizhi Huangqi decoction combined with TP regimen concurrent chemoradiotherapy on the percentage of carbon monoxide diffusion to estimated value(DLCO),level of serum vascular transforming growth factor(TGF-β1)and recurrence of patients with locally advanced non-small cell lung cancer(NSCLC).Methods:Totalyl 67 patients with locally advanced NSCLC admitted to our hospital from March 2017 to April 2019 were selected and divided into the observation group(n=34)and the control group(n=33)according to the order of admission.The control group was treated with TP regimen concurrent chemoradiotherapy,while the observation group was treated with Shuizhi Huangqi decoction on the basis of the control group.The shortterm efficacy,DLCO value,vital capacity(VC),serum TGF-β1 level,toxicity and recurrence were compared between the two groups.Results:The effective rate of the observation group was slightly higher than that of the control group,while there was no significant difference between the two groups(P>0.05);after treatment,the DLCO and VC values of the observation group were significantly higher than before treatment,and were significantly higher than those of the control group,and the level of serum TGF-β1 was significantly lower than that of the control group,and the differences were significant(P<0.05);the incidence of leukopenia in the observation group was significantly lower than that in the control group(P<0.05),while there was no significant difference in the incidences of thrombocytopenia,nausea and vomiting between the two groups(P>0.05).Conclusion:Shuizhi Huangqi decoction combined with TP regimen concurrent chemoradiotherapy is effective in the treatment of locally advanced NSCLC.It can improve pulmonary function to some extent,alleviate inflammation and toxicity,and reduce recurrence.

关 键 词：水蛭黄芪汤 TP方案 非小细胞肺癌 一氧化碳弥散量 血管转化生长因子 

分 类 号：R289.5[医药卫生—方剂学]