百令胶囊联合维生素E对甲减患者氧化、免疫功能及血小板活化的影响  

Effect of Bailing Capsule Combined with vitamin E on Oxidation,Immune Function and Platelet Activation in Hypothyroidism Patients

作　　者：赵换牢 雷飞 ZHAO Huan-lao;LEI Fei(Department of Endocrinology and metabolism,Joint service support force of The 987 th Hospital Chinese people’s Liberation Army,Baoji,721000,China;Department of Women’s Health,The maternal and Child Health Hospital of Xianyang,Xianyang,712000,China)

机构地区：[1]中国人民解放军联勤保障部队第987医院内分泌代谢科,宝鸡721000 [2]咸阳市妇幼保健院妇女保健部,咸阳712000

出　　处：《血栓与止血学》2020年第4期566-568,共3页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的探讨百令胶囊联合维生素E对甲减患者氧化、免疫功能及血小板活化的影响。方法选择2017年8月到2019年5月在本院内分泌科诊治的甲减患者172例作为研究对象,根据治疗方法的不同分为观察组100例与对照组72例。对照组给予维生素E治疗,观察组在对照组治疗的基础上给予百令胶囊治疗,两组都给予左旋甲状腺素治疗,治疗观察8周。结果观察组总有效率为98.0%,显著高于对照组的88.9%(P<0.05)。两组在治疗期间的不良反应主要为心悸、失眠、头痛等,对比差异无统计学意义(P>0.05)。治疗后两组的血清C-反应蛋白(C-reactive protein,CRP)、促甲状腺激素(Thyroid-stimulating hormone,TSH)含量都低于治疗前(P<0.05),观察组也显著低于对照组(P<0.05),治疗后观察组患者的P选择素水平显著低于对照组(P<0.05)。结论百令胶囊联合维生素E辅助治疗甲减能缓解患者氧化应激状态,提高免疫功能与总体疗效,抑制血小板活化,且不增加不良反应。Objective To explore the effects of Bailing capsules combined with vitamin E on oxidation and immune function in patients with hypothyroidism.Methods from August 2017 to May 2019,a total of 172 cases of patients with hypothyroidism diagnosed and treated in the endocrinology department of our hospital were selected as the research subjects and were divided into observation group of 100 cases and control group of 72 cases accorded to different treatment methods.The control group were given vitamin E treatment,and the observation group were given Bailing capsules on the basis of the treatment of the control group.Both groups were given levothyroxine for 8 weeks.Results The total effective rates in the observation group were 98.0%,higher than 88.9%in the control group(P<0.05).The adverse reactions during the treatment of the two groups were mainly palpitations,insomnia,and headache,and there were no significant difference in comparison(P>0.05).The levels of serum C-reactive protein(CRP)and Thyroid-stimulating hormone(TSH)in the two groups after treatment were lower than before treatment(P<0.05),and the observation group were significantly lower than the control group.(P<0.05).After treatment,P-selecter level significantly lower than control groutp(P<0.05).Conclusion Bailing Capsules combined with vitamin E in adjuvant treatment of hypothyroidism patients can alleviate the oxidative stress function,improve the patient’s immune function and overall efficacy,Inhibit platelet activation,without increasing the adverse reactions.

关 键 词：百令胶囊 维生素E 甲减 免疫功能 血小板活化 

分 类 号：R58[医药卫生—内分泌]