减重手术改善代谢的新机制  

The novel mechanisms of weight-loss surgery in improving metabolism

作　　者：陈莹[1] 刘子荣[2] Chen Ying;Liu Zirong(Department of Surgery,Tianjin Occupational Diseases Precaution and Therapeutic Hospital,Tianjin 300011,China;Department of Hepatobiliary Surgery,Tianjin First Central Hospital,Tianjin 300192,China)

机构地区：[1]天津市职业病防治院外科,300011 [2]天津市第一中心医院肝胆外科,300192

出　　处：《国际内分泌代谢杂志》2020年第4期275-278,共4页International Journal of Endocrinology and Metabolism

摘　　要：减重手术是治疗肥胖的有效手段之一,其可在有效减轻体重的同时,改善患者的代谢状况。减重手术可通过改变胃部结构使肠道菌群的组成发生改变,而后者可通过多种机制改善机体代谢。另外,减重手术还带来了表观遗传学方面的改变,进而对机体代谢产生有利影响。胆汁酸在调节机体代谢方面同样发挥重要作用,而减重手术可使胆汁酸水平升高。因此,减重手术可通过多种机制改善机体代谢。Weight-loss surgery is one of the effective methods to treat obesity,which can effectively reduce body weight and improve the metabolism of patients.Weight-loss surgery can change the composition of intestinal flora by changing the structure of the stomach,and the latter can improve the metabolism of the body through a variety of mechanisms.In addition,weight-loss surgery also brought about epigenetic changes,which in turn had a beneficial effect on metabolism.Bile acids also plays an important role in regulating metabolism,while weight-loss surgery can increase the level of bile acids.Therefore,weight-loss surgery can improve the metabolism of the body through a variety of mechanisms.

关 键 词：减重手术 代谢 肠道菌群 表观遗传学 

分 类 号：R656.61[医药卫生—外科学]