微环境中肿瘤细胞与免疫细胞之间的代谢对话及对免疫治疗的影响  

Metabolic crosstalk between tumor cells and immune cells in microenvironment and its effects on immunotherapy

作　　者：赵薇[1] 季国忠[2] ZHAO Wei;JI Guozhong(Department of Pathology,Nanjing Hospital Affiliated to Nanjing Medical University,Nanjing 210006;Digestive Medicine Center,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China)

机构地区：[1]南京医科大学附属南京医院病理科,江苏南京210006 [2]南京医科大学第二附属医院消化医学中心,江苏南京210011

出　　处：《南京医科大学学报（自然科学版）》2020年第6期779-782,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省科学技术厅重点研发专项基金(BE2016799)。

摘　　要：肿瘤是一种动态的假器官,包含着多种细胞类型,它们之间相互作用,形成一个独特的网络。在这个网络中,恶性细胞的生存遇到许多挑战,并相应地对它们的代谢特性进行重新编程。这种改变可以通过与肿瘤内其他细胞,特别是免疫细胞的相互作用而实现。肿瘤微环境的重建能引起机体病理生理反应并促进代谢重编程,这种不同细胞之间的相互作用被用来支持肿瘤的代谢和生长。利用这些过程的重要性和普遍性及在肿瘤发生和进展中的作用,设计新的靶向药物用于癌症治疗。因此,剖析肿瘤微环境中不同细胞间代谢重编程的特点将有助于设计新的免疫治疗方案和治疗策略,并为个体化精准医疗奠定基础。Tumor is a dynamic pseudoorgan,which contains a variety of cell types,and the interaction between them produces a unique network.In this network,the survival of malignant cells faces many challenges and their metabolic characteristics are reprogrammed accordingly.This change can be experienced and carried out by itself through interaction with other cells in the tumor,especially immune cells.The reconstruction of tumor microenvironment can cause pathophysiological reactions and promote metabolic reprogramming.This metabolic interaction between different cells is used to support tumor metabolism and growth.The importance and universality of these processes and their role in tumor development and progression are being used to design new drug targets and cancer treatments.Therefore,the analysis of the characteristics of different intercellular metabolic reprogramming in tumor microenvironment will help to provide new immunotherapy schemes and strategies,and lay the foundation for individualized precision medical treatment.

关 键 词：肿瘤微环境 代谢重编程 免疫治疗 

分 类 号：K730.231[历史地理—历史学]