Anti-inflammatory spirobisnaphthalene natural products from a plant-derived endophytic fungus Edenia gomezpompae  

作　　者：Yingzi Tan Zhikai Guo Mengyue Zhu Jing Shi Wei Li Ruihua Jiao Renxiang Tan Huiming Ge 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology,Institute of Functional Biomolecules,School of Life Sciences,Nanjing University,Nanjing 210023,China [2]Hainan Key Laboratory of Tropical Microbe Resources,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China [3]State Key Laboratory Cultivation Base for TCM Quality and Efficacy,Nanjing University of Chinese Medicine,Nanjing 210023,China [4]Hainan Academy of Tropical Agricultural Resource,Chinese Academy of Tropical Agricultural Sciences,Haikou 571101,China

出　　处：《Chinese Chemical Letters》2020年第6期1406-1409,F0002,共5页中国化学快报（英文版）

基　　金：financially supported by MOST(Nos.2018YFA0902000 and 2018YFC1706200);National Natural Science Foundation of China(Nos.81925033,21861142005,81773591,21761142001,81673333 and 21661140001);the Central Public-interest Scientific Institution Basal Research Fund for CATAS-ITBB(Nos.1630052020032,19CXTD-32 and 1630052019011);the Hainan Provincial Basic and Applied Basic Research Fund for High-Level Talents in Natural Science(No.2019RC306)。

摘　　要：Spirobisnaphthalenes comprise a relatively rare family of natural products that are normally isolated from fungi and occasionally from plants.Here we reported the discovery of seven new preussomerintype spirobisnaphthalenes,preussomerins YT1-YT7(1-7),and seven known ones(8-14),from the endophytic fungus Edenia gomezpompae,enriching the structural diversity of this family of natural products.Their structures were established by 1 D and 2 D NMR spectroscopy,HRESIMS analysis and comparison with previously reported compounds,with the absolute configurations of compounds 1 and2 being further confirmed by single-crystal X-ray diffraction using Cu Ka radiation.The antiinflammatory activities of all isolates were assessed by measuring the production of NO in LPS-induced RAW264.7 macrophage cells.Among them,compounds 8 and 13 exhibited potent inhibitory activities on the production of NO,with IC50 values of 2.61 and 1.32μmol/L,respectively.

关 键 词：Endophytic fungus Spirobisnaphthalene natural products Preussomerin-type Structure elucidation Anti-inflammatory activity 

分 类 号：TQ28[化学工程—有机化工]