1,3-Dipolar cycloaddition for selective synthesis of functionalized spiro[indoline-3,3’-pyrrolizines]  

作　　者：Meijun Zhu Ying Han Changzhou Liu Weiqing Ma Chao-Guo Yan 

机构地区：[1]Jianghai Polytechnic College,Yangzhou 225101,China [2]College of Chemistry&Chemical Engineering,Yangzhou University,Yangzhou 225002,China

出　　处：《Chinese Chemical Letters》2020年第6期1554-1557,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(No.21572196);the Priority Academic Program Development of Jiangsu Higher Education Institutions,China。

摘　　要：The 1,3-dipolar cycloaddition reaction of dimethyl hex-2-en-4-ynedioate with azomethine ylides derived from reaction of L-proline with various isatins in methanol selectively resulted in the formation of functionalized spiro[indoline-3,3’-pyrrolizine]acrylates as main products and spiro[indoline-3,3’-pyrrolizine]propiolates as minor products.This result indicated that the electron-deficient alkyne has higher reactivity than that of electron-deficient alkene in 1,3-dipolar cycloaddition reaction.

关 键 词：Azomethine ylide Spirooxindoline L-PROLINE Electron-deficient alkyne 1 3-Dipolar cycloaddition reaction 

分 类 号：O626[理学—有机化学]