Rh(Ⅲ)-catalyzed C8 arylation of quinoline N-oxides with arylboronic acids  

作　　者：Yuanqiong Huang Xueli Lv Hongjian Song Yuxiu Liu Qingmin Wang 

机构地区：[1]State Key Laboratory of Elemento-Organic Chemistry,Research Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071,China [2]Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin 300071,China

出　　处：《Chinese Chemical Letters》2020年第6期1572-1575,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21977056,21732002,21672117,21602117,21772104,31760527);the Tianjin Natural Science Foundation(No.16JCZDJC32400)for generous financial support for our programs。

摘　　要：Herein,we report the first Rh~Ⅲ-catalyzed regioselective C8 arylation of quinoline N-oxides with commercially available arylboronic acids as coupling partners.This procedure is simple,and the reaction shows perfect regioselectivity,a broad substrate scope,and isolated yields of up to 92%.We demonstrate the utility of the reaction by using it for late-stage functionalization of a fungicide.

关 键 词：Rh^Ⅲ-catalyzed C8 arylation Quinoline N-oxides Arylboronic acids Regioselectivity 

分 类 号：O621.251[理学—有机化学]