Electrochemical synthesis of selenocyanated imidazo[1,5-a]quinolines under metal catalyst-and chemical oxidant-free conditions  

作　　者：Jinjin Zhang Huiqiao Wang Yaru Chen Haiquan Xie Chenghua Ding Jiajing Tan Kun Xu 

机构地区：[1]College of Chemistry and Pharmaceutical Engineering,Nanyang Normal University,Nanyang 473061,China [2]College of Life Science&Bioengineering,Beijing University of Technology,Beijing 100124,China[3]Department of Organic Chemistry,Faculty of Chemistry,Beijing University of Chemical Technology,Beijing 100029,China

出　　处：《Chinese Chemical Letters》2020年第6期1576-1579,共4页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.21602119,21702013);the Foundation of He’nan Educational Committee(No.16A150057);Program for Science and Technology Innovation Talents in Universities of Henan Province(No.19HASTIT033);the Beijing Natural Science Foundation(No.2184115);the Fundamental Research Funds for the Central Universities(Nos.XK1802-6,buctrc201721)。

摘　　要：Reported herein is the first example of electrochemical selenocyanation of imidazo[1,5-a]quinolines with KSeCN under metal catalyst-and chemical oxidant-free conditions.This sustainable strategy shows a broad scope and great compatibility with functional groups,and affords synthetically and biologically important selenocyanated imidazo[1,5-a]quinolines in good to excellent yields with cheap graphite and Ni plates as the electrodes.The gram-scale synthesis was also successfully conducted,which might demonstrate the potential value of this electrochemical protocol.

关 键 词：ELECTROSYNTHESIS Organic electrochemistry Anodic oxidation Imidazo[1 5-a]quinoline Selenocyanation 

分 类 号：O626[理学—有机化学]