荷丹片治疗冠心病血运重建术后11819例患者回顾性队列研究  

Retrospective Cohort Study on Hedan Tablets for 11819 Cases of Patients with Coronary Heart Disease After Revascularization

作　　者：冯雪 李四维 高翔 吴岳 杜柳 解文娟 王微微 刁晓林 张雪 赵韡 FENG Xue;LI Siwei;GAO Xiang;WU Yue;DU Liu;XIE Wenjuan;WANG Weiwei;DIAO Xiaolin;ZHANG Xue;ZHAO Wei

机构地区：[1]中国医学科学院阜外医院心脏康复中心,北京100037 [2]北京京煤集团总医院,北京102300 [3]北京市丰台区铁营医院,北京100079 [4]中国医学科学院阜外医院信息中心,北京100037

出　　处：《新中医》2020年第13期73-77,共5页New Chinese Medicine

摘　　要：目的:基于回顾性队列研究,评价不同治疗剂量荷丹片对冠心病血运重建术后患者血脂代谢、肝功能、肾功能的影响。方法:选取冠心病血运重建术后患者11819例,根据世界卫生组织年龄分段标准,将纳入患者分为青年组、中年组及老年组,在常规西药治疗的基础上,按照服用荷丹片的情况,再将各年龄组患者分为非暴露A组(未使用荷丹片)、低暴露B组(用量在1~5 d)、强暴露C组(用量>5 d),观察各年龄组患者在荷丹片不同剂量下血脂指标、肝功能、肾功能指标变化情况。结果:青年组治疗后,非暴露A组、低暴露B组、强暴露C组3组总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平均较治疗前下降(P<0.05),但组间比较差异无统计学意义(P>0.05)。老年组治疗后,非暴露A组、低暴露B组、强暴露C组3组TC、LDL-C水平均较治疗前下降(P<0.05),强暴露C组降低最为明显,且组间比较,差异有统计学意义(P<0.05);治疗后,非暴露A组、低暴露B组、强暴露C组3组HDL-C水平均较治疗前下降(P<0.05),但组间比较,差异无统计学意义(P>0.05)。治疗后,青年组3组的谷丙转氨酶(ALT)、谷草转氨酶(AST)、血肌酐(Cr)水平与治疗前没有显著差异(P>0.05);中年组3组和老年组3组的ALT、AST、Cr水平较治疗前升高(P<0.05)。结论:在常规西药治疗基础上,加用荷丹片对老年患者具有轻微降低TC、LDL-C的优势,服用5 d以上优势更显著,且荷丹片对所有年龄段患者的安全性良好。Objective:Based on retrospective cohort study,to evaluate the effect of Hedan tablets at different therapeutic dosage on blood lipid metabolism,the liver function and the kidney function in patients with coronary heart disease after revascularization.Methods:A total of 11819 cases of patients with coronary heart disease after revascularization were selected.According to WHO criteria of age division,the enrolled patients were divided into the young group,the middle age group and the senile group.Based on routine western medicine treatment,according to the condition of oral administration of Hedan tablets,patients in each age group were divided into the non-exposed group A who didn’t use Hedan tablets,the low-exposed group B at dosage between one to five days,and the high-exposed group C at dosage more than five days.With Hedan tablets at different therapeutic dosage,the changes in the indexes of blood lipid metabolism,the liver function and the kidney function in each age group were observed.Results:In the young group,after treatment,the levels of TC,HDL-C and LDL-C in the non-exposed group A,the low-exposed group B and the highexposed group C were decreased when compared with those before treatment(P<0.05),but there being no significance in the difference among the groups(P>0.05).In the senile group,after treatment,the levels of TC and LDL-C in the nonexposed group A,the low-exposed group B and the high-exposed group C were decreased when compared with those before treatment(P<0.05),and the decease in the high-exposed group C was most significant,and the difference among the groups being significant(P<0.05);after treatment,the levels of HDL-C in the above three groups were decreased when compared with those before treatment(P<0.05),but there being no significance in the difference among the groups(P>0.05).After treatment,there was no significant difference being found in the levels of ALT,AST and Cr in the three groups of the young group(P>0.05);in the three groups of the middle age and those of the senile grou

关 键 词：冠心病 血运重建术后 荷丹片 血脂 回顾性队列研究 

分 类 号：R541.4[医药卫生—心血管疾病]