薄荷素油纳米乳的制备  

Preparation of peppermint oil nanoemulsion

作　　者：杨安平[1] 钟多敏 梁一俊 杜卓[1] YANG An-ping;ZHONG Duo-min;LIANG Yi-jun;DU Zhuo(School of Parmaceutical Engineering,Foshan University,Guangdong Foshan 528000,China)

机构地区：[1]佛山科学技术学院医药工程学院,广东佛山528000

出　　处：《中国医院药学杂志》2020年第12期1349-1353,共5页Chinese Journal of Hospital Pharmacy

基　　金：国家自然科学基金项目(编号:81901881)。

摘　　要：目的:研究探索制备薄荷素油纳米乳的处方。方法:采用转向法制备薄荷素油纳米乳,通过滴定法绘制伪三元相图,以纳米乳区域的面积、稳定性为考察指标,筛选薄荷素油纳米乳最佳处方。通过稀释法鉴定薄荷素油纳米乳类型、透射电子显微镜观察其外观形态、激光粒度测定仪测定其粒径分布、电位。结果:薄荷素油纳米乳优选处方结果为:表面活性剂为蓖麻油聚氧乙烯醚(EL-40)、助表面活性剂为聚乙二醇400(PEG-400),K_m为3∶1,薄荷素油、复表面活性剂、蒸馏水含量为56.62%∶23.67%∶19.72%;所制得薄荷素油纳米乳为澄清透明,平均粒径为19.55 nm,PDI为0.183,呈正态分布,Zeta电位为3.10 mV。结论:薄荷素油纳米乳制备工艺简单,采用优选处方制备的薄荷素油纳米乳粒径小、大小均匀。OBJECTIVE To explore the prescription of peppermint oil nanoemulsion.METHODS The peppermint oil nanoemulsion was prepared by the steering method.The pseudo-ternary phase diagram was drawn by titration method.The area and stability of the nanoemulsion region were used as indicators to select the optimal formulation of pept oil nanoemulsion.The type of peppermint oil nanoemulsion was identified by dilution method,its appearance morphology was observed by transmission electron microscopy,and its particle size distribution and potential were determined by laser particle size analyzer.RESULTS The optimal formulation of peppermint oil nanoemulsion was as follows:the surfactant was castor oil polyoxyethylene ether(EL-40),the cosurfactant was polyethylene glycol 400(PEG-400),the K_m was 3∶1,the content of peppermint oil,complex surfactant and distilled water was 56.62%∶23.67%∶19.72%;the prepared peppermint oil nanoemulsion was clear and transparent,the average particle size was 19.55 nm,the PDI was 0.183,showing a normal distribution,and the zeta potential was 3.10 mV.CONCLUSION The preparation process of peppermint oil nanoemulsion was simple,and the nanoemulsion prepared by the optimal prescription has oil droplet of small particle size and uniform size.

关 键 词：薄荷素油 纳米乳 伪三元相图 

分 类 号：R944[医药卫生—药剂学]