孕早期血脂相关指标预测非肥胖型患者子痫前期发生的临床价值  

The clinical value of lipid-related indicators in early pregnancy in predicting the occurrence of preeclampsia in non-obesity patients

作　　者：王佩佩 华玉蓉 严义栋 朱佳尔 龚萍 赵敏[2] WANG Peipei;HUA Yurong;YAN Yidong;ZHU Jiaer;GONG Ping;ZHAO Min(Department of Obstetrics and Gynecology,Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu 214000,China;Department of Obstetrics and Gynecology,Wuxi Maternal and Child Health Care Hospital,Wuxi,Jiangsu 214000,China)

机构地区：[1]江南大学附属医院妇产科,江苏无锡214000 [2]江苏省无锡市妇幼保健院妇产科,江苏无锡214000

出　　处：《国际检验医学杂志》2020年第15期1800-1802,1809,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(81100437);2018年江苏省无锡市卫生和计划生育委员会中医药科研项目(ZYZD201801)。

摘　　要：目的探讨孕早期血脂相关指标预测非肥胖型患者子痫前期发生的价值。方法选取非肥胖子痫前期孕妇102例作为子痫前期组,另选择非肥胖健康孕妇98例作为对照组。比较两组孕妇孕10周相关血脂指标水平,探讨影响子痫前期发生的危险因素。结果子痫前期组孕妇孕10周三酰甘油、低密度脂蛋白胆固醇(LDL-C)、动脉粥样硬化指数、总胆固醇/高密度脂蛋白胆固醇(HDL-C)及LDL-C/HDL-C均明显高于对照组,差异均有统计学意义(P<0.05);LDL-C/HDL-C(OR=7.498)为最终影响子痫前期发生的危险因素;当LDL-C/HDL-C取2.12(最佳截断值)时预测是否为子痫前期的灵敏度、特异度分别为81.2%、61.9%,受试者工作特征曲线下面积为0.801。结论血脂代谢异常特别是孕早期LDL-C/HDL-C是影响子痫前期发生的危险因素,可作为一项辅助指标早期预测子痫前期的发生。Objective To investigate the value of lipid-related indexes in early pregnancy in predicting preeclampsia in non-obesity patients.Methods A total of 102 non-obesity preeclampsia pregnant women were collected as preeclampsia group,and 98 non-obesity healthy pregnant women were selected as control group.The risk factors affecting preeclampsia were investigated by comparing the lipid-related indicators in 10 weeks of pregnancy.Results The levels of triacylglycerol,low density lipoprotein cholesterol(LDL-C),atherosclerosis index,total cholesterol/high density lipoprotein cholesterol(HDL-C)and LDL-C/HDL-C in 10 weeks of pregnancy in the preeclampsia group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).LDL-C/HDL-C(OR=7.498)was a risk factor that ultimately affected preeclampsia.When LDL-C/HDL-C was 2.12(the best cut-off value),the sensitivity and the specificity in predicting preeclampsia were 81.2%and 61.9%,respectively,and the area under the curve was 0.801.Conclusion Dyslipidemia,especially LDL-C/HDL-C in early pregnancy,is a risk factor of preeclampsia,which can be used as an auxiliary index to predict the occurrence of preeclampsia.

关 键 词：孕早期 血脂 非肥胖 子痫前期 

分 类 号：R714.7[医药卫生—妇产科学]